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Anti-CCN2/ CTGF/ HCS24 monoclonal antibody
Anti-CCN2/ CTGF/ HCS24 antibody for FACS & in-vivo assay
Go to CTGF/CCN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T50444-Ab-1/ GM-Tg-hg-T50444-Ab-2 | Anti-Human CTGF/CCN2 monoclonal antibody | Human |
| GM-Tg-rg-T50444-Ab-1/ GM-Tg-rg-T50444-Ab-2 | Anti-Rat CTGF/CCN2 monoclonal antibody | Rat |
| GM-Tg-mg-T50444-Ab-1/ GM-Tg-mg-T50444-Ab-2 | Anti-Mouse CTGF/CCN2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T50444-Ab-1/ GM-Tg-cynog-T50444-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CTGF/CCN2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T50444-Ab-1/ GM-Tg-felg-T50444-Ab-2 | Anti-Feline CTGF/CCN2 monoclonal antibody | Feline |
| GM-Tg-cang-T50444-Ab-1/ GM-Tg-cang-T50444-Ab-2 | Anti-Canine CTGF/CCN2 monoclonal antibody | Canine |
| GM-Tg-bovg-T50444-Ab-1/ GM-Tg-bovg-T50444-Ab-2 | Anti-Bovine CTGF/CCN2 monoclonal antibody | Bovine |
| GM-Tg-equg-T50444-Ab-1/ GM-Tg-equg-T50444-Ab-2 | Anti-Equine CTGF/CCN2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T50444-Ab-1/ GM-Tg-hg-T50444-Ab-2; GM-Tg-rg-T50444-Ab-1/ GM-Tg-rg-T50444-Ab-2; GM-Tg-mg-T50444-Ab-1/ GM-Tg-mg-T50444-Ab-2; GM-Tg-cynog-T50444-Ab-1/ GM-Tg-cynog-T50444-Ab-2; GM-Tg-felg-T50444-Ab-1/ GM-Tg-felg-T50444-Ab-2; GM-Tg-cang-T50444-Ab-1/ GM-Tg-cang-T50444-Ab-2; GM-Tg-bovg-T50444-Ab-1/ GM-Tg-bovg-T50444-Ab-2; GM-Tg-equg-T50444-Ab-1/ GM-Tg-equg-T50444-Ab-2 |
| Products Name | Anti-CTGF/CCN2 monoclonal antibody |
| Format | mab |
| Target Name | CTGF |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CTGF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-424 | Pre-Made Pamrevlumab biosimilar, Whole mAb, Anti-CTGF/CCN2 Antibody: Anti-HCS24/IGFBP8/NOV2 therapeutic antibody |
| Target Antigen | Products Developing | Multi-species CCN2/ CTGF/ HCS24 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T50444-Ag-1 | connective tissue growth factor (CTGF) protein |
| ORF Viral Vector | vGMAD000129 | human CTGF Adenovirus particle |
| ORF Viral Vector | pGMAD000129 | human CTGF Adenovirus plasmid |
| ORF Viral Vector | pGMLPm003832 | mouse Ctgf Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003832 | mouse Ctgf Lentivirus particle |
Target information
| Target ID | GM-T50444 |
| Target Name | CTGF |
| Gene ID | 1490,14219,64032,714520,476202,101094598,281103,100073098 |
| Gene Symbol and Synonyms | CCN2,CTGF,CTGRP,fisp-12,Fisp12,HCS24,IGFBP8,NOV2 |
| Uniprot Accession | P29279,Q9R1E9,O18739 |
| Uniprot Entry Name | CCN2_HUMAN,CCN2_RAT,CCN2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Ovary Cancer, Chronic Kidney Disease, Type 1 diabetes mellitus with diabetic nephropathy, gastric cancer, Complications of kidney transplant |
| Gene Ensembl | ENSG00000118523 |
| Target Classification | N/A |
The target: CTGF, gene name: CCN2, also named as CTGF, HCS24, IGFBP8, NOV2. The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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