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Anti-Lin-28A monoclonal antibody
Pre-made anti-Lin-28A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to Lin-28A/LIN28A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T49593-Ab-1/ GM-Tg-hg-T49593-Ab-2 | Anti-Human Lin-28A/LIN28A monoclonal antibody | Human |
| GM-Tg-rg-T49593-Ab-1/ GM-Tg-rg-T49593-Ab-2 | Anti-Rat Lin-28A/LIN28A monoclonal antibody | Rat |
| GM-Tg-mg-T49593-Ab-1/ GM-Tg-mg-T49593-Ab-2 | Anti-Mouse Lin-28A/LIN28A monoclonal antibody | Mouse |
| GM-Tg-cynog-T49593-Ab-1/ GM-Tg-cynog-T49593-Ab-2 | Anti-Cynomolgus/ Rhesus macaque Lin-28A/LIN28A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T49593-Ab-1/ GM-Tg-felg-T49593-Ab-2 | Anti-Feline Lin-28A/LIN28A monoclonal antibody | Feline |
| GM-Tg-cang-T49593-Ab-1/ GM-Tg-cang-T49593-Ab-2 | Anti-Canine Lin-28A/LIN28A monoclonal antibody | Canine |
| GM-Tg-bovg-T49593-Ab-1/ GM-Tg-bovg-T49593-Ab-2 | Anti-Bovine Lin-28A/LIN28A monoclonal antibody | Bovine |
| GM-Tg-equg-T49593-Ab-1/ GM-Tg-equg-T49593-Ab-2 | Anti-Equine Lin-28A/LIN28A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T49593-Ab-1/ GM-Tg-hg-T49593-Ab-2; GM-Tg-rg-T49593-Ab-1/ GM-Tg-rg-T49593-Ab-2; GM-Tg-mg-T49593-Ab-1/ GM-Tg-mg-T49593-Ab-2; GM-Tg-cynog-T49593-Ab-1/ GM-Tg-cynog-T49593-Ab-2; GM-Tg-felg-T49593-Ab-1/ GM-Tg-felg-T49593-Ab-2; GM-Tg-cang-T49593-Ab-1/ GM-Tg-cang-T49593-Ab-2; GM-Tg-bovg-T49593-Ab-1/ GM-Tg-bovg-T49593-Ab-2; GM-Tg-equg-T49593-Ab-1/ GM-Tg-equg-T49593-Ab-2 |
| Products Name | Anti-Lin-28A/LIN28A monoclonal antibody |
| Format | mab |
| Target Name | Lin-28A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-Lin-28A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T49593-Ag-1 | Recombinant multi-species LN28A/ Lin-28A/ LIN28A protein |
| ORF Viral Vector | pGMAP000263 | Human LIN28 Adenovirus plasmid |
| ORF Viral Vector | pGMLV000061 | human LIN28A Lentivirus plasmid |
| ORF Viral Vector | vGMLV000061 | human LIN28A Lentivirus particle |
| ORF Viral Vector | vGMAP000263 | Human LIN28 Adenovirus particle |
| ORF Viral Vector | pGMLPm001127 | mouse Lin28a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001127 | mouse Lin28a Lentivirus particle |
Target information
| Target ID | GM-T49593 |
| Target Name | Lin-28A |
| Gene ID | 79727,83557,500562,719865,102151926,100379627,614997,100071098 |
| Gene Symbol and Synonyms | CSDD1,Gm10299,LIN-28,lin-28A,LIN28,LIN28A,RGD1566408,Tex17,ZCCHC1 |
| Uniprot Accession | Q9H9Z2 |
| Uniprot Entry Name | LN28A_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | N/A |
| Gene Ensembl | ENSG00000131914 |
| Target Classification | N/A |
The target: Lin-28A, gene name: LIN28A, also named as CSDD1, LIN-28, LIN28, ZCCHC1, lin-28A. This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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