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Anti-NEK2 monoclonal antibody
Pre-made anti-NEK2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to NEK2/NEK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T49102-Ab-1/ GM-Tg-hg-T49102-Ab-2 | Anti-Human NEK2 monoclonal antibody | Human |
| GM-Tg-rg-T49102-Ab-1/ GM-Tg-rg-T49102-Ab-2 | Anti-Rat NEK2 monoclonal antibody | Rat |
| GM-Tg-mg-T49102-Ab-1/ GM-Tg-mg-T49102-Ab-2 | Anti-Mouse NEK2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T49102-Ab-1/ GM-Tg-cynog-T49102-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NEK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T49102-Ab-1/ GM-Tg-felg-T49102-Ab-2 | Anti-Feline NEK2 monoclonal antibody | Feline |
| GM-Tg-cang-T49102-Ab-1/ GM-Tg-cang-T49102-Ab-2 | Anti-Canine NEK2 monoclonal antibody | Canine |
| GM-Tg-bovg-T49102-Ab-1/ GM-Tg-bovg-T49102-Ab-2 | Anti-Bovine NEK2 monoclonal antibody | Bovine |
| GM-Tg-equg-T49102-Ab-1/ GM-Tg-equg-T49102-Ab-2 | Anti-Equine NEK2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T49102-Ab-1/ GM-Tg-hg-T49102-Ab-2; GM-Tg-rg-T49102-Ab-1/ GM-Tg-rg-T49102-Ab-2; GM-Tg-mg-T49102-Ab-1/ GM-Tg-mg-T49102-Ab-2; GM-Tg-cynog-T49102-Ab-1/ GM-Tg-cynog-T49102-Ab-2; GM-Tg-felg-T49102-Ab-1/ GM-Tg-felg-T49102-Ab-2; GM-Tg-cang-T49102-Ab-1/ GM-Tg-cang-T49102-Ab-2; GM-Tg-bovg-T49102-Ab-1/ GM-Tg-bovg-T49102-Ab-2; GM-Tg-equg-T49102-Ab-1/ GM-Tg-equg-T49102-Ab-2 |
| Products Name | Anti-NEK2 monoclonal antibody |
| Format | mab |
| Target Name | NEK2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-NEK2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T49102-Ag-1 | Recombinant multi-species NEK2/ HsPK21A/ NLK1 protein |
| ORF Viral Vector | vGMLP001403 | human NEK2 Lentivirus particle |
| ORF Viral Vector | pGMLP001403 | human NEK2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001689 | mouse Nek2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001689 | mouse Nek2 Lentivirus particle |
Target information
| Target ID | GM-T49102 |
| Target Name | NEK2 |
| Gene ID | 4751,18005,114482,711473,480021,101085774,523998,100054759 |
| Gene Symbol and Synonyms | HsPK21,NEK2,NEK2A,NLK1,PPP1R111,RP67 |
| Uniprot Accession | P51955 |
| Uniprot Entry Name | NEK2_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000117650 |
| Target Classification | Kinase |
The target: NEK2, gene name: NEK2, also named as HsPK21A, NLK1, PPP1R111, RP67, NEK2. This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene. [provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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