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Anti-KRAS monoclonal antibody
Pre-made anti-KRAS monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KRAS/KRAS products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T48598-Ab-1/ GM-Tg-hg-T48598-Ab-2 | Anti-Human KRAS monoclonal antibody | Human |
| GM-Tg-rg-T48598-Ab-1/ GM-Tg-rg-T48598-Ab-2 | Anti-Rat KRAS monoclonal antibody | Rat |
| GM-Tg-mg-T48598-Ab-1/ GM-Tg-mg-T48598-Ab-2 | Anti-Mouse KRAS monoclonal antibody | Mouse |
| GM-Tg-cynog-T48598-Ab-1/ GM-Tg-cynog-T48598-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KRAS monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T48598-Ab-1/ GM-Tg-felg-T48598-Ab-2 | Anti-Feline KRAS monoclonal antibody | Feline |
| GM-Tg-cang-T48598-Ab-1/ GM-Tg-cang-T48598-Ab-2 | Anti-Canine KRAS monoclonal antibody | Canine |
| GM-Tg-bovg-T48598-Ab-1/ GM-Tg-bovg-T48598-Ab-2 | Anti-Bovine KRAS monoclonal antibody | Bovine |
| GM-Tg-equg-T48598-Ab-1/ GM-Tg-equg-T48598-Ab-2 | Anti-Equine KRAS monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T48598-Ab-1/ GM-Tg-hg-T48598-Ab-2; GM-Tg-rg-T48598-Ab-1/ GM-Tg-rg-T48598-Ab-2; GM-Tg-mg-T48598-Ab-1/ GM-Tg-mg-T48598-Ab-2; GM-Tg-cynog-T48598-Ab-1/ GM-Tg-cynog-T48598-Ab-2; GM-Tg-felg-T48598-Ab-1/ GM-Tg-felg-T48598-Ab-2; GM-Tg-cang-T48598-Ab-1/ GM-Tg-cang-T48598-Ab-2; GM-Tg-bovg-T48598-Ab-1/ GM-Tg-bovg-T48598-Ab-2; GM-Tg-equg-T48598-Ab-1/ GM-Tg-equg-T48598-Ab-2 |
| Products Name | Anti-KRAS monoclonal antibody |
| Format | mab |
| Target Name | KRAS |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KRAS monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T48598-Ag-1 | Recombinant multi-species RASK/ KRAS/ C-K-RAS protein |
| ORF Viral Vector | pGMLP001960 | human KRAS Lentivirus plasmid |
| ORF Viral Vector | vGMLP001359 | human KRAS Lentivirus particle |
| ORF Viral Vector | pGMLP001359 | human KRAS Lentivirus plasmid |
| ORF Viral Vector | vGMLP001960 | human KRAS Lentivirus particle |
Target information
| Target ID | GM-T48598 |
| Target Name | KRAS |
| Gene ID | 3845,16653,24525,707977,403871,751104,541140,100064473 |
| Gene Symbol and Synonyms | 'C-K-RAS,C-K-RAS,c-Ki-ras,c-Ki-ras2,CFC2,K-Ras,K-Ras 2,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,KI-RAS,KRAS,Kras-2,KRAS1,KRAS2,NS,NS3,OES,p21,p21B,p21ras,RALD,ras,RASK2 |
| Uniprot Accession | P01116,P08644 |
| Uniprot Entry Name | RASK_HUMAN,RASK_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | |
| Disease | Non-Small Cell Lung Cancer, Colorectal Cancer, Pancreas Cancer |
| Gene Ensembl | ENSG00000133703 |
| Target Classification | N/A |
The target: KRAS, gene name: KRAS, also named as C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, K-Ras, KI-RAS1, KRAS2, NS, NS3, RALD, RASK2, c-Ki-ras2, KRAS. This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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