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Anti-HMGA2 monoclonal antibody
Pre-made anti-HMGA2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to HMGA2/HMGA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T48166-Ab-1/ GM-Tg-hg-T48166-Ab-2 | Anti-Human HMGA2 monoclonal antibody | Human |
| GM-Tg-rg-T48166-Ab-1/ GM-Tg-rg-T48166-Ab-2 | Anti-Rat HMGA2 monoclonal antibody | Rat |
| GM-Tg-mg-T48166-Ab-1/ GM-Tg-mg-T48166-Ab-2 | Anti-Mouse HMGA2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T48166-Ab-1/ GM-Tg-cynog-T48166-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HMGA2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T48166-Ab-1/ GM-Tg-felg-T48166-Ab-2 | Anti-Feline HMGA2 monoclonal antibody | Feline |
| GM-Tg-cang-T48166-Ab-1/ GM-Tg-cang-T48166-Ab-2 | Anti-Canine HMGA2 monoclonal antibody | Canine |
| GM-Tg-bovg-T48166-Ab-1/ GM-Tg-bovg-T48166-Ab-2 | Anti-Bovine HMGA2 monoclonal antibody | Bovine |
| GM-Tg-equg-T48166-Ab-1/ GM-Tg-equg-T48166-Ab-2 | Anti-Equine HMGA2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T48166-Ab-1/ GM-Tg-hg-T48166-Ab-2; GM-Tg-rg-T48166-Ab-1/ GM-Tg-rg-T48166-Ab-2; GM-Tg-mg-T48166-Ab-1/ GM-Tg-mg-T48166-Ab-2; GM-Tg-cynog-T48166-Ab-1/ GM-Tg-cynog-T48166-Ab-2; GM-Tg-felg-T48166-Ab-1/ GM-Tg-felg-T48166-Ab-2; GM-Tg-cang-T48166-Ab-1/ GM-Tg-cang-T48166-Ab-2; GM-Tg-bovg-T48166-Ab-1/ GM-Tg-bovg-T48166-Ab-2; GM-Tg-equg-T48166-Ab-1/ GM-Tg-equg-T48166-Ab-2 |
| Products Name | Anti-HMGA2 monoclonal antibody |
| Format | mab |
| Target Name | HMGA2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-HMGA2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T48166-Ag-1 | Recombinant multi-species HMGA2/ BABL/ HMGI-C protein |
| ORF Viral Vector | pGMLV000254 | human HMGA2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000253 | human HMGA2 Lentivirus particle |
| ORF Viral Vector | vGMLV000254 | human HMGA2 Lentivirus particle |
| ORF Viral Vector | pGMLV000253 | human HMGA2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000256 | mouse Hmga2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000256 | mouse Hmga2 Lentivirus particle |
Target information
| Target ID | GM-T48166 |
| Target Name | HMGA2 |
| Gene ID | 8091,15364,84017,717721,100271859,111561386,100297155,102149270 |
| Gene Symbol and Synonyms | 9430083A20Rik,BABL,HMGA2,HMGI-C,HMGIC,LIPO,pg,pygmy,SRS5,STQTL9 |
| Uniprot Accession | P52926 |
| Uniprot Entry Name | HMGA2_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000149948 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: HMGA2, gene name: HMGA2, also named as BABL, HMGI-C, HMGIC, LIPO, STQTL9. This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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