Anti-LTK/ TYK1 monoclonal antibody

Anti-LTK/ TYK1 antibody for FACS & in-vivo assay

Target products collectionGo to LTK/LTK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T47657-Ab-1/ GM-Tg-hg-T47657-Ab-2Anti-Human LTK monoclonal antibodyHuman
GM-Tg-rg-T47657-Ab-1/ GM-Tg-rg-T47657-Ab-2Anti-Rat LTK monoclonal antibodyRat
GM-Tg-mg-T47657-Ab-1/ GM-Tg-mg-T47657-Ab-2Anti-Mouse LTK monoclonal antibodyMouse
GM-Tg-cynog-T47657-Ab-1/ GM-Tg-cynog-T47657-Ab-2Anti-Cynomolgus/ Rhesus macaque LTK monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T47657-Ab-1/ GM-Tg-felg-T47657-Ab-2Anti-Feline LTK monoclonal antibodyFeline
GM-Tg-cang-T47657-Ab-1/ GM-Tg-cang-T47657-Ab-2Anti-Canine LTK monoclonal antibodyCanine
GM-Tg-bovg-T47657-Ab-1/ GM-Tg-bovg-T47657-Ab-2Anti-Bovine LTK monoclonal antibodyBovine
GM-Tg-equg-T47657-Ab-1/ GM-Tg-equg-T47657-Ab-2Anti-Equine LTK monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T47657-Ab-1/ GM-Tg-hg-T47657-Ab-2; GM-Tg-rg-T47657-Ab-1/ GM-Tg-rg-T47657-Ab-2;
GM-Tg-mg-T47657-Ab-1/ GM-Tg-mg-T47657-Ab-2; GM-Tg-cynog-T47657-Ab-1/ GM-Tg-cynog-T47657-Ab-2;
GM-Tg-felg-T47657-Ab-1/ GM-Tg-felg-T47657-Ab-2; GM-Tg-cang-T47657-Ab-1/ GM-Tg-cang-T47657-Ab-2;
GM-Tg-bovg-T47657-Ab-1/ GM-Tg-bovg-T47657-Ab-2; GM-Tg-equg-T47657-Ab-1/ GM-Tg-equg-T47657-Ab-2
Products NameAnti-LTK monoclonal antibody
Formatmab
Target NameLTK
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LTK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LTK/ TYK1 VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T47657
    Target NameLTK
    Gene ID4058,17005,311337,710624,100688547,123386239,100071149
    Gene Symbol and SynonymsLTK,TYK1
    Uniprot AccessionP29376
    Uniprot Entry NameLTK_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000062524
    Target ClassificationKinase

    The target: LTK, gene name: LTK, also named as TYK1. The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.