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Anti-ACV1B/ ACVR1B/ ACTRIB monoclonal antibody
Anti-ACV1B/ ACVR1B/ ACTRIB antibody for FACS & in-vivo assay
Go to ACVR1B/ACVR1B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T47594-Ab-1/ GM-Tg-hg-T47594-Ab-2 | Anti-Human ACVR1B monoclonal antibody | Human |
| GM-Tg-rg-T47594-Ab-1/ GM-Tg-rg-T47594-Ab-2 | Anti-Rat ACVR1B monoclonal antibody | Rat |
| GM-Tg-mg-T47594-Ab-1/ GM-Tg-mg-T47594-Ab-2 | Anti-Mouse ACVR1B monoclonal antibody | Mouse |
| GM-Tg-cynog-T47594-Ab-1/ GM-Tg-cynog-T47594-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ACVR1B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T47594-Ab-1/ GM-Tg-felg-T47594-Ab-2 | Anti-Feline ACVR1B monoclonal antibody | Feline |
| GM-Tg-cang-T47594-Ab-1/ GM-Tg-cang-T47594-Ab-2 | Anti-Canine ACVR1B monoclonal antibody | Canine |
| GM-Tg-bovg-T47594-Ab-1/ GM-Tg-bovg-T47594-Ab-2 | Anti-Bovine ACVR1B monoclonal antibody | Bovine |
| GM-Tg-equg-T47594-Ab-1/ GM-Tg-equg-T47594-Ab-2 | Anti-Equine ACVR1B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T47594-Ab-1/ GM-Tg-hg-T47594-Ab-2; GM-Tg-rg-T47594-Ab-1/ GM-Tg-rg-T47594-Ab-2; GM-Tg-mg-T47594-Ab-1/ GM-Tg-mg-T47594-Ab-2; GM-Tg-cynog-T47594-Ab-1/ GM-Tg-cynog-T47594-Ab-2; GM-Tg-felg-T47594-Ab-1/ GM-Tg-felg-T47594-Ab-2; GM-Tg-cang-T47594-Ab-1/ GM-Tg-cang-T47594-Ab-2; GM-Tg-bovg-T47594-Ab-1/ GM-Tg-bovg-T47594-Ab-2; GM-Tg-equg-T47594-Ab-1/ GM-Tg-equg-T47594-Ab-2 |
| Products Name | Anti-ACVR1B monoclonal antibody |
| Format | mab |
| Target Name | ACVR1B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ACVR1B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACV1B/ ACVR1B/ ACTRIB VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T47594-Ag-1 | activin A receptor, type IB (ACVR1B) protein |
| ORF Viral Vector | pGMLV000171 | mouse Acvr1b Lentivirus plasmid |
| ORF Viral Vector | vGMLV000171 | mouse Acvr1b Lentivirus particle |
Target information
| Target ID | GM-T47594 |
| Target Name | ACVR1B |
| Gene ID | 91,11479,29381,696587,486537,101097654,539315,100062619 |
| Gene Symbol and Synonyms | 6820432J04,ActR-IB,ACTRIB,ACVR1B,ACVRLK4,ALK-4,ALK4,SKR2 |
| Uniprot Accession | P36896,P80202 |
| Uniprot Entry Name | ACV1B_HUMAN,ACV1B_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000135503 |
| Target Classification | Kinase |
The target: ACVR1B, gene name: ACVR1B, also named as ACTRIB, ACVRLK4, ALK4, SKR2. This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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