Anti-AVR2A/ ACVR2A/ ACTRII monoclonal antibody

Anti-AVR2A/ ACVR2A/ ACTRII antibody for FACS & in-vivo assay

Target products collectionGo to ACVR2A/ACVR2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T47366-Ab-1/ GM-Tg-hg-T47366-Ab-2Anti-Human ACVR2A monoclonal antibodyHuman
GM-Tg-rg-T47366-Ab-1/ GM-Tg-rg-T47366-Ab-2Anti-Rat ACVR2A monoclonal antibodyRat
GM-Tg-mg-T47366-Ab-1/ GM-Tg-mg-T47366-Ab-2Anti-Mouse ACVR2A monoclonal antibodyMouse
GM-Tg-cynog-T47366-Ab-1/ GM-Tg-cynog-T47366-Ab-2Anti-Cynomolgus/ Rhesus macaque ACVR2A monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T47366-Ab-1/ GM-Tg-felg-T47366-Ab-2Anti-Feline ACVR2A monoclonal antibodyFeline
GM-Tg-cang-T47366-Ab-1/ GM-Tg-cang-T47366-Ab-2Anti-Canine ACVR2A monoclonal antibodyCanine
GM-Tg-bovg-T47366-Ab-1/ GM-Tg-bovg-T47366-Ab-2Anti-Bovine ACVR2A monoclonal antibodyBovine
GM-Tg-equg-T47366-Ab-1/ GM-Tg-equg-T47366-Ab-2Anti-Equine ACVR2A monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T47366-Ab-1/ GM-Tg-hg-T47366-Ab-2; GM-Tg-rg-T47366-Ab-1/ GM-Tg-rg-T47366-Ab-2;
GM-Tg-mg-T47366-Ab-1/ GM-Tg-mg-T47366-Ab-2; GM-Tg-cynog-T47366-Ab-1/ GM-Tg-cynog-T47366-Ab-2;
GM-Tg-felg-T47366-Ab-1/ GM-Tg-felg-T47366-Ab-2; GM-Tg-cang-T47366-Ab-1/ GM-Tg-cang-T47366-Ab-2;
GM-Tg-bovg-T47366-Ab-1/ GM-Tg-bovg-T47366-Ab-2; GM-Tg-equg-T47366-Ab-1/ GM-Tg-equg-T47366-Ab-2
Products NameAnti-ACVR2A monoclonal antibody
Formatmab
Target NameACVR2A
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ACVR2A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species AVR2A/ ACVR2A/ ACTRII VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T47366-Ag-1activin A receptor, type IIA (ACVR2A) protein
    ORF Viral VectorpGMLP004152human ACVR2A Lentivirus plasmid
    ORF Viral VectorvGMLP004152human ACVR2A Lentivirus particle
    ORF Viral VectorpGMLPm004265mouse Acvr2a Lentivirus plasmid
    ORF Viral VectorvGMLPm004265mouse Acvr2a Lentivirus particle


    Target information

    Target IDGM-T47366
    Target NameACVR2A
    Gene ID92,11480,29263,707017,476140,101097750,281598,100049823
    Gene Symbol and SynonymsACTRII,ActrIIa,ACVR2,ACVR2A,rActR-II,TactrII
    Uniprot AccessionP27037,P38444,Q28043
    Uniprot Entry NameAVR2A_HUMAN,AVR2A_RAT,AVR2A_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000121989
    Target ClassificationKinase

    The target: ACVR2A, gene name: ACVR2A, also named as ACTRII, ACVR2. This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.