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Anti-NK1R/ TACR1/ NKIR monoclonal antibody
Anti-NK1R/ TACR1/ NKIR antibody for FACS & in-vivo assay
Go to TACR1/TACR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T47094-Ab-1/ GM-Tg-hg-T47094-Ab-2 | Anti-Human TACR1 monoclonal antibody | Human |
| GM-Tg-rg-T47094-Ab-1/ GM-Tg-rg-T47094-Ab-2 | Anti-Rat TACR1 monoclonal antibody | Rat |
| GM-Tg-mg-T47094-Ab-1/ GM-Tg-mg-T47094-Ab-2 | Anti-Mouse TACR1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T47094-Ab-1/ GM-Tg-cynog-T47094-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TACR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T47094-Ab-1/ GM-Tg-felg-T47094-Ab-2 | Anti-Feline TACR1 monoclonal antibody | Feline |
| GM-Tg-cang-T47094-Ab-1/ GM-Tg-cang-T47094-Ab-2 | Anti-Canine TACR1 monoclonal antibody | Canine |
| GM-Tg-bovg-T47094-Ab-1/ GM-Tg-bovg-T47094-Ab-2 | Anti-Bovine TACR1 monoclonal antibody | Bovine |
| GM-Tg-equg-T47094-Ab-1/ GM-Tg-equg-T47094-Ab-2 | Anti-Equine TACR1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T47094-Ab-1/ GM-Tg-hg-T47094-Ab-2; GM-Tg-rg-T47094-Ab-1/ GM-Tg-rg-T47094-Ab-2; GM-Tg-mg-T47094-Ab-1/ GM-Tg-mg-T47094-Ab-2; GM-Tg-cynog-T47094-Ab-1/ GM-Tg-cynog-T47094-Ab-2; GM-Tg-felg-T47094-Ab-1/ GM-Tg-felg-T47094-Ab-2; GM-Tg-cang-T47094-Ab-1/ GM-Tg-cang-T47094-Ab-2; GM-Tg-bovg-T47094-Ab-1/ GM-Tg-bovg-T47094-Ab-2; GM-Tg-equg-T47094-Ab-1/ GM-Tg-equg-T47094-Ab-2 |
| Products Name | Anti-TACR1 monoclonal antibody |
| Format | mab |
| Target Name | TACR1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TACR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NK1R/ TACR1/ NKIR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001583 | human TACR1 Lentivirus particle |
| ORF Viral Vector | pGMLP001583 | human TACR1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002627 | mouse Tacr1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002627 | mouse Tacr1 Lentivirus particle |
Target information
| Target ID | GM-T47094 |
| Target Name | TACR1 |
| Gene ID | 6869,21336,24807,653008,403815,101090094,407133,100053491 |
| Gene Symbol and Synonyms | NK-1,NK1R,NKIR,SPR,TAC1R,TACR1 |
| Uniprot Accession | P25103,P14600,Q5DUB3 |
| Uniprot Entry Name | NK1R_HUMAN,NK1R_RAT,NK1R_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000115353 |
| Target Classification | GPCR, Tumor-associated antigen (TAA) |
The target: TACR1, gene name: TACR1, also named as NK1R, NKIR, SPR, TAC1R. This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P. [provided by RefSeq, Sep 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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