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Anti-SO1B1/ SLCO1B1/ HBLRR monoclonal antibody
Anti-SO1B1/ SLCO1B1/ HBLRR antibody for FACS & in-vivo assay
Go to SLCO1B1/SLCO1B1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T46814-Ab-1/ GM-Tg-hg-T46814-Ab-2 | Anti-Human SLCO1B1 monoclonal antibody | Human |
| GM-Tg-rg-T46814-Ab-1/ GM-Tg-rg-T46814-Ab-2 | Anti-Rat SLCO1B1 monoclonal antibody | Rat |
| GM-Tg-mg-T46814-Ab-1/ GM-Tg-mg-T46814-Ab-2 | Anti-Mouse SLCO1B1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T46814-Ab-1/ GM-Tg-cynog-T46814-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SLCO1B1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T46814-Ab-1/ GM-Tg-felg-T46814-Ab-2 | Anti-Feline SLCO1B1 monoclonal antibody | Feline |
| GM-Tg-cang-T46814-Ab-1/ GM-Tg-cang-T46814-Ab-2 | Anti-Canine SLCO1B1 monoclonal antibody | Canine |
| GM-Tg-bovg-T46814-Ab-1/ GM-Tg-bovg-T46814-Ab-2 | Anti-Bovine SLCO1B1 monoclonal antibody | Bovine |
| GM-Tg-equg-T46814-Ab-1/ GM-Tg-equg-T46814-Ab-2 | Anti-Equine SLCO1B1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T46814-Ab-1/ GM-Tg-hg-T46814-Ab-2; GM-Tg-rg-T46814-Ab-1/ GM-Tg-rg-T46814-Ab-2; GM-Tg-mg-T46814-Ab-1/ GM-Tg-mg-T46814-Ab-2; GM-Tg-cynog-T46814-Ab-1/ GM-Tg-cynog-T46814-Ab-2; GM-Tg-felg-T46814-Ab-1/ GM-Tg-felg-T46814-Ab-2; GM-Tg-cang-T46814-Ab-1/ GM-Tg-cang-T46814-Ab-2; GM-Tg-bovg-T46814-Ab-1/ GM-Tg-bovg-T46814-Ab-2; GM-Tg-equg-T46814-Ab-1/ GM-Tg-equg-T46814-Ab-2 |
| Products Name | Anti-SLCO1B1 monoclonal antibody |
| Format | mab |
| Target Name | SLCO1B1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-SLCO1B1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species SO1B1/ SLCO1B1/ HBLRR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000189 | human SLCO1B1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000189 | human SLCO1B1 Lentivirus particle |
Target information
| Target ID | GM-T46814 |
| Target Name | SLCO1B1 |
| Gene ID | 10599,705308 |
| Gene Symbol and Synonyms | HBLRR,LST-1,LST1,OATP-C,OATP1B1,OATP2,OATPC,SLC21A6,SLCO1B1 |
| Uniprot Accession | Q9Y6L6 |
| Uniprot Entry Name | SO1B1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | |
| Disease | Cancer |
| Gene Ensembl | ENSG00000134538 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: SLCO1B1, gene name: SLCO1B1, also named as HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6. This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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