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Anti-FETUA/ AHSG/ A2HS functional antibody
Anti-FETUA/ AHSG/ A2HS functional antibody for cell culture, ELISA & in-vivo assay
Go to AHSG/AHSG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T45289-Ab-1/ GM-Tg-hg-T45289-Ab-2 | Anti-Human AHSG monoclonal antibody | Human |
| GM-Tg-rg-T45289-Ab-1/ GM-Tg-rg-T45289-Ab-2 | Anti-Rat AHSG monoclonal antibody | Rat |
| GM-Tg-mg-T45289-Ab-1/ GM-Tg-mg-T45289-Ab-2 | Anti-Mouse AHSG monoclonal antibody | Mouse |
| GM-Tg-cynog-T45289-Ab-1/ GM-Tg-cynog-T45289-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AHSG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T45289-Ab-1/ GM-Tg-felg-T45289-Ab-2 | Anti-Feline AHSG monoclonal antibody | Feline |
| GM-Tg-cang-T45289-Ab-1/ GM-Tg-cang-T45289-Ab-2 | Anti-Canine AHSG monoclonal antibody | Canine |
| GM-Tg-bovg-T45289-Ab-1/ GM-Tg-bovg-T45289-Ab-2 | Anti-Bovine AHSG monoclonal antibody | Bovine |
| GM-Tg-equg-T45289-Ab-1/ GM-Tg-equg-T45289-Ab-2 | Anti-Equine AHSG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T45289-Ab-1/ GM-Tg-hg-T45289-Ab-2; GM-Tg-rg-T45289-Ab-1/ GM-Tg-rg-T45289-Ab-2; GM-Tg-mg-T45289-Ab-1/ GM-Tg-mg-T45289-Ab-2; GM-Tg-cynog-T45289-Ab-1/ GM-Tg-cynog-T45289-Ab-2; GM-Tg-felg-T45289-Ab-1/ GM-Tg-felg-T45289-Ab-2; GM-Tg-cang-T45289-Ab-1/ GM-Tg-cang-T45289-Ab-2; GM-Tg-bovg-T45289-Ab-1/ GM-Tg-bovg-T45289-Ab-2; GM-Tg-equg-T45289-Ab-1/ GM-Tg-equg-T45289-Ab-2 |
| Products Name | Anti-AHSG monoclonal antibody |
| Format | mab |
| Target Name | AHSG |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-AHSG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T45289-Ag-1 | Recombinant multi-species FETUA/ AHSG/ A2HS protein |
| ORF Viral Vector | pGMLPm003808 | mouse Ahsg Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003808 | mouse Ahsg Lentivirus particle |
Target information
| Target ID | GM-T45289 |
| Target Name | AHSG |
| Gene ID | 197,11625,25373,699348,607538,101099828,280988,100068067 |
| Gene Symbol and Synonyms | A2HS,Aa2-066,AHS,AHSG,APMR1,BSP,FETUA,HSGA,pp63 |
| Uniprot Accession | P02765,P24090,P12763 |
| Uniprot Entry Name | FETUA_HUMAN,FETUA_RAT,FETUA_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | leukemia patients, Diabetic Nephropathy, Type 2 diabetes mellitus |
| Gene Ensembl | ENSG00000145192 |
| Target Classification | N/A |
The target: AHSG, gene name: AHSG, also named as A2HS, AHS, APMR1, FETUA, HSGA. The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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