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Anti-GLUC/ GCG/ GLP-1 functional antibody
Anti-GLUC/ GCG/ GLP-1 functional antibody for cell culture, ELISA & in-vivo assay
Go to GCG/GCG products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T44919-Ab-1/ GM-Tg-hg-T44919-Ab-2 | Anti-Human GCG monoclonal antibody | Human |
| GM-Tg-rg-T44919-Ab-1/ GM-Tg-rg-T44919-Ab-2 | Anti-Rat GCG monoclonal antibody | Rat |
| GM-Tg-mg-T44919-Ab-1/ GM-Tg-mg-T44919-Ab-2 | Anti-Mouse GCG monoclonal antibody | Mouse |
| GM-Tg-cynog-T44919-Ab-1/ GM-Tg-cynog-T44919-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GCG monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T44919-Ab-1/ GM-Tg-felg-T44919-Ab-2 | Anti-Feline GCG monoclonal antibody | Feline |
| GM-Tg-cang-T44919-Ab-1/ GM-Tg-cang-T44919-Ab-2 | Anti-Canine GCG monoclonal antibody | Canine |
| GM-Tg-bovg-T44919-Ab-1/ GM-Tg-bovg-T44919-Ab-2 | Anti-Bovine GCG monoclonal antibody | Bovine |
| GM-Tg-equg-T44919-Ab-1/ GM-Tg-equg-T44919-Ab-2 | Anti-Equine GCG monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T44919-Ab-1/ GM-Tg-hg-T44919-Ab-2; GM-Tg-rg-T44919-Ab-1/ GM-Tg-rg-T44919-Ab-2; GM-Tg-mg-T44919-Ab-1/ GM-Tg-mg-T44919-Ab-2; GM-Tg-cynog-T44919-Ab-1/ GM-Tg-cynog-T44919-Ab-2; GM-Tg-felg-T44919-Ab-1/ GM-Tg-felg-T44919-Ab-2; GM-Tg-cang-T44919-Ab-1/ GM-Tg-cang-T44919-Ab-2; GM-Tg-bovg-T44919-Ab-1/ GM-Tg-bovg-T44919-Ab-2; GM-Tg-equg-T44919-Ab-1/ GM-Tg-equg-T44919-Ab-2 |
| Products Name | Anti-GCG monoclonal antibody |
| Format | mab |
| Target Name | GCG |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GCG benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T44919-Ag-1 | Recombinant multi-species GLUC/ GCG/ GLP-1 protein |
| ORF Viral Vector | vGMLP002234 | human GCG Lentivirus particle |
| ORF Viral Vector | pGMLP002234 | human GCG Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000645 | mouse Gcg Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000645 | mouse Gcg Lentivirus particle |
Target information
| Target ID | GM-T44919 |
| Target Name | GCG |
| Gene ID | 2641,14526,24952,705508,403571,101097825,280802,100051551 |
| Gene Symbol and Synonyms | GCG,GLP-1,GLP-2,GLP1,GLP2,Glu,GRPP,PPG |
| Uniprot Accession | P01275,P06883,P29794,P01272 |
| Uniprot Entry Name | GLUC_HUMAN,GLUC_RAT,GLUC_CANLF,GLUC_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000115263 |
| Target Classification | N/A |
The target: GCG, gene name: GCG, also named as GLP-1, GLP1, GLP2, GRPP. The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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