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Anti-NOTC3/ NOTCH3/ CADASIL monoclonal antibody
Anti-NOTC3/ NOTCH3/ CADASIL antibody for FACS & in-vivo assay
Go to NOTCH3/NOTCH3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T44684-Ab-1/ GM-Tg-hg-T44684-Ab-2 | Anti-Human NOTCH3 monoclonal antibody | Human |
| GM-Tg-rg-T44684-Ab-1/ GM-Tg-rg-T44684-Ab-2 | Anti-Rat NOTCH3 monoclonal antibody | Rat |
| GM-Tg-mg-T44684-Ab-1/ GM-Tg-mg-T44684-Ab-2 | Anti-Mouse NOTCH3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T44684-Ab-1/ GM-Tg-cynog-T44684-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NOTCH3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T44684-Ab-1/ GM-Tg-felg-T44684-Ab-2 | Anti-Feline NOTCH3 monoclonal antibody | Feline |
| GM-Tg-cang-T44684-Ab-1/ GM-Tg-cang-T44684-Ab-2 | Anti-Canine NOTCH3 monoclonal antibody | Canine |
| GM-Tg-bovg-T44684-Ab-1/ GM-Tg-bovg-T44684-Ab-2 | Anti-Bovine NOTCH3 monoclonal antibody | Bovine |
| GM-Tg-equg-T44684-Ab-1/ GM-Tg-equg-T44684-Ab-2 | Anti-Equine NOTCH3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T44684-Ab-1/ GM-Tg-hg-T44684-Ab-2; GM-Tg-rg-T44684-Ab-1/ GM-Tg-rg-T44684-Ab-2; GM-Tg-mg-T44684-Ab-1/ GM-Tg-mg-T44684-Ab-2; GM-Tg-cynog-T44684-Ab-1/ GM-Tg-cynog-T44684-Ab-2; GM-Tg-felg-T44684-Ab-1/ GM-Tg-felg-T44684-Ab-2; GM-Tg-cang-T44684-Ab-1/ GM-Tg-cang-T44684-Ab-2; GM-Tg-bovg-T44684-Ab-1/ GM-Tg-bovg-T44684-Ab-2; GM-Tg-equg-T44684-Ab-1/ GM-Tg-equg-T44684-Ab-2 |
| Products Name | Anti-NOTCH3 monoclonal antibody |
| Format | mab |
| Target Name | NOTCH3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NOTCH3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-551 | Pre-Made Tarextumab biosimilar, Whole mAb, Anti-NOTCH2&3 Antibody: Anti-AGS2/HJCYS/hN2;CADASIL/CADASIL1/CASIL/IMF2/LMNS therapeutic antibody |
| Target Antigen | Products Developing | Multi-species NOTC3/ NOTCH3/ CADASIL VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T44684-Ag-1 | notch 3 (NOTCH3) protein |
Target information
| Target ID | GM-T44684 |
| Target Name | NOTCH3 |
| Gene ID | 4854,18131,56761,719119,610439,101088469,789485,100146771 |
| Gene Symbol and Synonyms | CADASIL,CADASIL1,CASIL,hpbk,IMF2,LMNS,N3,NOTCH3 |
| Uniprot Accession | Q9UM47,Q9R172 |
| Uniprot Entry Name | NOTC3_HUMAN,NOTC3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000074181 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: NOTCH3, gene name: NOTCH3, also named as CADASIL, CADASIL1, CASIL, IMF2, LMNS. This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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