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Anti-IL19/ IL-10C/ MDA1 functional antibody
Anti-IL19/ IL-10C/ MDA1 functional antibody for cell culture, ELISA & in-vivo assay
Go to IL19/IL19 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T44584-Ab-1/ GM-Tg-hg-T44584-Ab-2 | Anti-Human IL19 monoclonal antibody | Human |
| GM-Tg-rg-T44584-Ab-1/ GM-Tg-rg-T44584-Ab-2 | Anti-Rat IL19 monoclonal antibody | Rat |
| GM-Tg-mg-T44584-Ab-1/ GM-Tg-mg-T44584-Ab-2 | Anti-Mouse IL19 monoclonal antibody | Mouse |
| GM-Tg-cynog-T44584-Ab-1/ GM-Tg-cynog-T44584-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL19 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T44584-Ab-1/ GM-Tg-felg-T44584-Ab-2 | Anti-Feline IL19 monoclonal antibody | Feline |
| GM-Tg-cang-T44584-Ab-1/ GM-Tg-cang-T44584-Ab-2 | Anti-Canine IL19 monoclonal antibody | Canine |
| GM-Tg-bovg-T44584-Ab-1/ GM-Tg-bovg-T44584-Ab-2 | Anti-Bovine IL19 monoclonal antibody | Bovine |
| GM-Tg-equg-T44584-Ab-1/ GM-Tg-equg-T44584-Ab-2 | Anti-Equine IL19 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T44584-Ab-1/ GM-Tg-hg-T44584-Ab-2; GM-Tg-rg-T44584-Ab-1/ GM-Tg-rg-T44584-Ab-2; GM-Tg-mg-T44584-Ab-1/ GM-Tg-mg-T44584-Ab-2; GM-Tg-cynog-T44584-Ab-1/ GM-Tg-cynog-T44584-Ab-2; GM-Tg-felg-T44584-Ab-1/ GM-Tg-felg-T44584-Ab-2; GM-Tg-cang-T44584-Ab-1/ GM-Tg-cang-T44584-Ab-2; GM-Tg-bovg-T44584-Ab-1/ GM-Tg-bovg-T44584-Ab-2; GM-Tg-equg-T44584-Ab-1/ GM-Tg-equg-T44584-Ab-2 |
| Products Name | Anti-IL19 monoclonal antibody |
| Format | mab |
| Target Name | IL19 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL19 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T44584-Ag-1 | Recombinant multi-species IL19/ IL-10C/ MDA1 protein |
| Cytokine | GM-Tg-g-T44584-Ag-1 | IL19 (IL19) protein |
| ORF Viral Vector | pGMLP004788 | human IL19 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004788 | human IL19 Lentivirus particle |
| ORF Viral Vector | pGMLPm000299 | mouse Il19 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000299 | mouse Il19 Lentivirus particle |
Target information
| Target ID | GM-T44584 |
| Target Name | IL19 |
| Gene ID | 29949,329244,681145,694806,490265,101090582,527634,100055588 |
| Gene Symbol and Synonyms | IL-10C,IL19,MDA1,NG.1,ZMDA1 |
| Uniprot Accession | Q9UHD0 |
| Uniprot Entry Name | IL19_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000142224 |
| Target Classification | N/A |
The target: IL19, gene name: IL19, also named as IL-10C, MDA1, NG.1, ZMDA1. The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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