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Anti-TR11B/ TNFRSF11B/ OCIF monoclonal antibody
Anti-TR11B/ TNFRSF11B/ OCIF antibody for FACS & in-vivo assay
Go to TNFRSF11B/TNFRSF11B products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T43928-Ab-1/ GM-Tg-hg-T43928-Ab-2 | Anti-Human TNFRSF11B monoclonal antibody | Human |
| GM-Tg-rg-T43928-Ab-1/ GM-Tg-rg-T43928-Ab-2 | Anti-Rat TNFRSF11B monoclonal antibody | Rat |
| GM-Tg-mg-T43928-Ab-1/ GM-Tg-mg-T43928-Ab-2 | Anti-Mouse TNFRSF11B monoclonal antibody | Mouse |
| GM-Tg-cynog-T43928-Ab-1/ GM-Tg-cynog-T43928-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNFRSF11B monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T43928-Ab-1/ GM-Tg-felg-T43928-Ab-2 | Anti-Feline TNFRSF11B monoclonal antibody | Feline |
| GM-Tg-cang-T43928-Ab-1/ GM-Tg-cang-T43928-Ab-2 | Anti-Canine TNFRSF11B monoclonal antibody | Canine |
| GM-Tg-bovg-T43928-Ab-1/ GM-Tg-bovg-T43928-Ab-2 | Anti-Bovine TNFRSF11B monoclonal antibody | Bovine |
| GM-Tg-equg-T43928-Ab-1/ GM-Tg-equg-T43928-Ab-2 | Anti-Equine TNFRSF11B monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T43928-Ab-1/ GM-Tg-hg-T43928-Ab-2; GM-Tg-rg-T43928-Ab-1/ GM-Tg-rg-T43928-Ab-2; GM-Tg-mg-T43928-Ab-1/ GM-Tg-mg-T43928-Ab-2; GM-Tg-cynog-T43928-Ab-1/ GM-Tg-cynog-T43928-Ab-2; GM-Tg-felg-T43928-Ab-1/ GM-Tg-felg-T43928-Ab-2; GM-Tg-cang-T43928-Ab-1/ GM-Tg-cang-T43928-Ab-2; GM-Tg-bovg-T43928-Ab-1/ GM-Tg-bovg-T43928-Ab-2; GM-Tg-equg-T43928-Ab-1/ GM-Tg-equg-T43928-Ab-2 |
| Products Name | Anti-TNFRSF11B monoclonal antibody |
| Format | mab |
| Target Name | TNFRSF11B |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNFRSF11B benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TR11B/ TNFRSF11B/ OCIF VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T43928-Ag-1 | tumor necrosis factor receptor superfamily, member 11b (TNFRSF11B) protein |
| ORF Viral Vector | pGMLP001906 | human TNFRSF11B Lentivirus plasmid |
| ORF Viral Vector | vGMLP001906 | human TNFRSF11B Lentivirus particle |
| ORF Viral Vector | pGMLPm001507 | mouse Tnfrsf11b Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001507 | mouse Tnfrsf11b Lentivirus particle |
Target information
| Target ID | GM-T43928 |
| Target Name | TNFRSF11B |
| Gene ID | 4982,18383,25341,701850,100855848,101096878,523822,100065885 |
| Gene Symbol and Synonyms | OCIF,OPG,PDB5,TNFRSF11B,TR1 |
| Uniprot Accession | O00300,O08727,A5D7R1 |
| Uniprot Entry Name | TR11B_HUMAN,TR11B_RAT,TR11B_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Breast Cancer, Diabetic Nephropathy, Type 2 diabetes mellitus, Lupus Glomerulonephritis |
| Gene Ensembl | ENSG00000164761 |
| Target Classification | N/A |
The target: TNFRSF11B, gene name: TNFRSF11B, also named as OCIF, OPG, PDB5, TR1. The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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