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Anti-RUNX1 monoclonal antibody
Pre-made anti-RUNX1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to RUNX1/RUNX1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T43711-Ab-1/ GM-Tg-hg-T43711-Ab-2 | Anti-Human RUNX1 monoclonal antibody | Human |
| GM-Tg-rg-T43711-Ab-1/ GM-Tg-rg-T43711-Ab-2 | Anti-Rat RUNX1 monoclonal antibody | Rat |
| GM-Tg-mg-T43711-Ab-1/ GM-Tg-mg-T43711-Ab-2 | Anti-Mouse RUNX1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T43711-Ab-1/ GM-Tg-cynog-T43711-Ab-2 | Anti-Cynomolgus/ Rhesus macaque RUNX1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T43711-Ab-1/ GM-Tg-felg-T43711-Ab-2 | Anti-Feline RUNX1 monoclonal antibody | Feline |
| GM-Tg-cang-T43711-Ab-1/ GM-Tg-cang-T43711-Ab-2 | Anti-Canine RUNX1 monoclonal antibody | Canine |
| GM-Tg-bovg-T43711-Ab-1/ GM-Tg-bovg-T43711-Ab-2 | Anti-Bovine RUNX1 monoclonal antibody | Bovine |
| GM-Tg-equg-T43711-Ab-1/ GM-Tg-equg-T43711-Ab-2 | Anti-Equine RUNX1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T43711-Ab-1/ GM-Tg-hg-T43711-Ab-2; GM-Tg-rg-T43711-Ab-1/ GM-Tg-rg-T43711-Ab-2; GM-Tg-mg-T43711-Ab-1/ GM-Tg-mg-T43711-Ab-2; GM-Tg-cynog-T43711-Ab-1/ GM-Tg-cynog-T43711-Ab-2; GM-Tg-felg-T43711-Ab-1/ GM-Tg-felg-T43711-Ab-2; GM-Tg-cang-T43711-Ab-1/ GM-Tg-cang-T43711-Ab-2; GM-Tg-bovg-T43711-Ab-1/ GM-Tg-bovg-T43711-Ab-2; GM-Tg-equg-T43711-Ab-1/ GM-Tg-equg-T43711-Ab-2 |
| Products Name | Anti-RUNX1 monoclonal antibody |
| Format | mab |
| Target Name | RUNX1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-RUNX1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T43711-Ag-1 | Recombinant multi-species RUNX1/ AML1/ AML1-EVI-1 protein |
| ORF Viral Vector | pGMLV000843 | human RUNX1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000314 | human RUNX1 Lentivirus particle |
| ORF Viral Vector | pGMLV000314 | human RUNX1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000843 | human RUNX1 Lentivirus particle |
| ORF Viral Vector | pGMLV000473 | house mouse Runx1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002038 | mouse Runx1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000473 | house mouse Runx1 Lentivirus particle |
| ORF Viral Vector | vGMLPm002038 | mouse Runx1 Lentivirus particle |
Target information
| Target ID | GM-T43711 |
| Target Name | RUNX1 |
| Gene ID | 861,12394,50662,696749,487746,101084898,529631,100051950 |
| Gene Symbol and Synonyms | AML1,AML1-EVI-1,AMLCR1,CBF-alpha-2,CBF2alpha,CBFA2,EVI-1,PEA2-alpha,PEBP2-alpha,Pebp2a2,PEBP2aB,PEBP2alpha,Pebpa2b,RUNX1 |
| Uniprot Accession | Q01196,Q63046 |
| Uniprot Entry Name | RUNX1_HUMAN,RUNX1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000159216 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: RUNX1, gene name: RUNX1, also named as AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha. Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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