Anti-PTPRC/ B220/ CD45 monoclonal antibody

Product information

Catalog No.	Product Name	Species Reactivity
GM-Tg-hg-T43115-Ab-1/ GM-Tg-hg-T43115-Ab-2	Anti-Human PTPRC monoclonal antibody	Human
GM-Tg-hg-T43115-Ab-3/ GM-Tg-hg-T43115-Ab-4	Anti-Human PTPRC monoclonal antibody	Human
GM-Tg-rg-T43115-Ab-1/ GM-Tg-rg-T43115-Ab-2	Anti-Rat PTPRC monoclonal antibody	Rat
GM-Tg-mg-T43115-Ab-1/ GM-Tg-mg-T43115-Ab-2	Anti-Mouse PTPRC monoclonal antibody	Mouse
GM-Tg-cynog-T43115-Ab-1/ GM-Tg-cynog-T43115-Ab-2	Anti-Cynomolgus/ Rhesus macaque PTPRC monoclonal antibody	Cynomolgus/ Rhesus macaque
GM-Tg-felg-T43115-Ab-1/ GM-Tg-felg-T43115-Ab-2	Anti-Feline PTPRC monoclonal antibody	Feline
GM-Tg-cang-T43115-Ab-1/ GM-Tg-cang-T43115-Ab-2	Anti-Canine PTPRC monoclonal antibody	Canine
GM-Tg-bovg-T43115-Ab-1/ GM-Tg-bovg-T43115-Ab-2	Anti-Bovine PTPRC monoclonal antibody	Bovine
GM-Tg-equg-T43115-Ab-1/ GM-Tg-equg-T43115-Ab-2	Anti-Equine PTPRC monoclonal antibody	Equine

Size： 1mg | 10mg | 100mg

Product Description

Catalog No.	GM-Tg-hg-T43115-Ab-1/ GM-Tg-hg-T43115-Ab-2; GM-Tg-hg-T43115-Ab-3/ GM-Tg-hg-T43115-Ab-4; GM-Tg-rg-T43115-Ab-1/ GM-Tg-rg-T43115-Ab-2; GM-Tg-mg-T43115-Ab-1/ GM-Tg-mg-T43115-Ab-2; GM-Tg-cynog-T43115-Ab-1/ GM-Tg-cynog-T43115-Ab-2; GM-Tg-felg-T43115-Ab-1/ GM-Tg-felg-T43115-Ab-2; GM-Tg-cang-T43115-Ab-1/ GM-Tg-cang-T43115-Ab-2; GM-Tg-bovg-T43115-Ab-1/ GM-Tg-bovg-T43115-Ab-2; GM-Tg-equg-T43115-Ab-1/ GM-Tg-equg-T43115-Ab-2
Products Name	Anti-PTPRC monoclonal antibody
Format	mab
Target Name	PTPRC
Protein Sub-location	Transmembrane Protein
Category of antibody	FACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)	Mouse/Human
CH1+2+3 Isotype (Receptor identification)	IgG
Type of Light Chain (VD-LC)	N/A
Expression platform	Mammalian Expression
Bioactivity validation	Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Tag	Fc
Products description	Pre-made anti-PTPRC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity	Purity: ≥95% (SDS-PAGE)
Application	Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution	Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O.
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference

Data / case study

Click to get more Data / Case study about the product.

Associated products

Category	Cat No.	Products Name
Biosimilar	GMP-Bios-ab-029	Pre-Made Apamistamab biosimilar, Whole mAb Radiolabelled, Anti-PTPRC Antibody: Anti-B220/CD45/CD45R/GP180/L-CA/LCA/LY5/T200 therapeutic antibody
Biosimilar	GMP-Bios-INN-875	Pre-Made Iodine (131I) Apamistamab Biosimilar, Radiolabelled Antibody, Anti-Ptprc Antibody: Anti-B220/CD45/CD45R/GP180/L-CA/LCA/LY5/T200 therapeutic antibody
Target Antigen	Products Developing	Multi-species PTPRC/ B220/ CD45 VLP (virus-like particle) (Products Developing)

Target information

Target ID	GM-T43115
Target Name	PTPRC
Gene ID	5788,19264,24699,712657,101097123,407152,100061950
Gene Symbol and Synonyms	B220,CD45,CD45R,GP180,IMD105,L-CA,LCA,loc,Ly-5,LY5,Lyt-4,PTPRC,RT7,T200
Uniprot Accession	P08575,P04157
Uniprot Entry Name	PTPRC_HUMAN,PTPRC_RAT
Protein Sub-location	Transmembrane Protein
Category	Therapeutics Target, INN Index
Disease	Cancer
Gene Ensembl	ENSG00000081237
Target Classification	Tumor-associated antigen (TAA)

The target: PTPRC, gene name: PTPRC, also named as B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012].

About Gmab