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Anti-IL17D/ IL27/ IL-17D functional antibody
Anti-IL17D/ IL27/ IL-17D functional antibody for cell culture, ELISA & in-vivo assay
Go to IL27/IL17D products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T41171-Ab-1/ GM-Tg-hg-T41171-Ab-2 | Anti-Human IL27/IL17D monoclonal antibody | Human |
| GM-Tg-rg-T41171-Ab-1/ GM-Tg-rg-T41171-Ab-2 | Anti-Rat IL27/IL17D monoclonal antibody | Rat |
| GM-Tg-mg-T41171-Ab-1/ GM-Tg-mg-T41171-Ab-2 | Anti-Mouse IL27/IL17D monoclonal antibody | Mouse |
| GM-Tg-cynog-T41171-Ab-1/ GM-Tg-cynog-T41171-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IL27/IL17D monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T41171-Ab-1/ GM-Tg-felg-T41171-Ab-2 | Anti-Feline IL27/IL17D monoclonal antibody | Feline |
| GM-Tg-cang-T41171-Ab-1/ GM-Tg-cang-T41171-Ab-2 | Anti-Canine IL27/IL17D monoclonal antibody | Canine |
| GM-Tg-bovg-T41171-Ab-1/ GM-Tg-bovg-T41171-Ab-2 | Anti-Bovine IL27/IL17D monoclonal antibody | Bovine |
| GM-Tg-equg-T41171-Ab-1/ GM-Tg-equg-T41171-Ab-2 | Anti-Equine IL27/IL17D monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T41171-Ab-1/ GM-Tg-hg-T41171-Ab-2; GM-Tg-rg-T41171-Ab-1/ GM-Tg-rg-T41171-Ab-2; GM-Tg-mg-T41171-Ab-1/ GM-Tg-mg-T41171-Ab-2; GM-Tg-cynog-T41171-Ab-1/ GM-Tg-cynog-T41171-Ab-2; GM-Tg-felg-T41171-Ab-1/ GM-Tg-felg-T41171-Ab-2; GM-Tg-cang-T41171-Ab-1/ GM-Tg-cang-T41171-Ab-2; GM-Tg-bovg-T41171-Ab-1/ GM-Tg-bovg-T41171-Ab-2; GM-Tg-equg-T41171-Ab-1/ GM-Tg-equg-T41171-Ab-2 |
| Products Name | Anti-IL27/IL17D monoclonal antibody |
| Format | mab |
| Target Name | IL27 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IL27 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T41171-Ag-1 | Recombinant multi-species IL17D/ IL27/ IL-17D protein |
| Cytokine | GM-Tg-g-T41171-Ag-1 | interleukin 17D (IL17D) protein |
| ORF Viral Vector | pGMLP003442 | human IL17D Lentivirus plasmid |
| ORF Viral Vector | vGMLP003442 | human IL17D Lentivirus particle |
Target information
| Target ID | GM-T41171 |
| Target Name | IL27 |
| Gene ID | 53342,239114,691799,721163,102156421,101093070,614982 |
| Gene Symbol and Synonyms | IL-17D,IL17D |
| Uniprot Accession | Q8TAD2 |
| Uniprot Entry Name | IL17D_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000172458 |
| Target Classification | N/A |
The target: IL27, gene name: IL17D, also named as IL-17D. The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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