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Anti-ELNE/ NE/ ELANE functional antibody
Anti-ELNE/ NE/ ELANE functional antibody for cell culture, ELISA & in-vivo assay
Go to NE/ELANE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T40332-Ab-1/ GM-Tg-hg-T40332-Ab-2 | Anti-Human NE/ELANE monoclonal antibody | Human |
| GM-Tg-rg-T40332-Ab-1/ GM-Tg-rg-T40332-Ab-2 | Anti-Rat NE/ELANE monoclonal antibody | Rat |
| GM-Tg-mg-T40332-Ab-1/ GM-Tg-mg-T40332-Ab-2 | Anti-Mouse NE/ELANE monoclonal antibody | Mouse |
| GM-Tg-cynog-T40332-Ab-1/ GM-Tg-cynog-T40332-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NE/ELANE monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T40332-Ab-1/ GM-Tg-felg-T40332-Ab-2 | Anti-Feline NE/ELANE monoclonal antibody | Feline |
| GM-Tg-cang-T40332-Ab-1/ GM-Tg-cang-T40332-Ab-2 | Anti-Canine NE/ELANE monoclonal antibody | Canine |
| GM-Tg-bovg-T40332-Ab-1/ GM-Tg-bovg-T40332-Ab-2 | Anti-Bovine NE/ELANE monoclonal antibody | Bovine |
| GM-Tg-equg-T40332-Ab-1/ GM-Tg-equg-T40332-Ab-2 | Anti-Equine NE/ELANE monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T40332-Ab-1/ GM-Tg-hg-T40332-Ab-2; GM-Tg-rg-T40332-Ab-1/ GM-Tg-rg-T40332-Ab-2; GM-Tg-mg-T40332-Ab-1/ GM-Tg-mg-T40332-Ab-2; GM-Tg-cynog-T40332-Ab-1/ GM-Tg-cynog-T40332-Ab-2; GM-Tg-felg-T40332-Ab-1/ GM-Tg-felg-T40332-Ab-2; GM-Tg-cang-T40332-Ab-1/ GM-Tg-cang-T40332-Ab-2; GM-Tg-bovg-T40332-Ab-1/ GM-Tg-bovg-T40332-Ab-2; GM-Tg-equg-T40332-Ab-1/ GM-Tg-equg-T40332-Ab-2 |
| Products Name | Anti-NE/ELANE monoclonal antibody |
| Format | mab |
| Target Name | NE |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T40332-Ag-1 | Recombinant multi-species ELNE/ NE/ ELANE protein |
| ORF Viral Vector | pGMLP004544 | human ELANE Lentivirus plasmid |
| ORF Viral Vector | vGMLP004544 | human ELANE Lentivirus particle |
| ORF Viral Vector | pGMLPm002774 | mouse Elane Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002774 | mouse Elane Lentivirus particle |
Target information
| Target ID | GM-T40332 |
| Target Name | NE |
| Gene ID | 1991,50701,299606,106992354,442980,100301482,100126050,111774155 |
| Gene Symbol and Synonyms | ELA2,ELANE,F430011M15Rik,GE,HLE,HNE,NE,PMN-E,SCN1 |
| Uniprot Accession | P08246 |
| Uniprot Entry Name | ELNE_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Interstitial cystitis (chronic) |
| Gene Ensembl | ENSG00000197561 |
| Target Classification | N/A |
The target: NE, gene name: ELANE, also named as ELA2, GE, HLE, HNE, NE, PMN-E, SCN1. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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