Anti-ELNE/ NE/ ELANE functional antibody

Anti-ELNE/ NE/ ELANE functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to NE/ELANE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T40332-Ab-1/ GM-Tg-hg-T40332-Ab-2Anti-Human NE/ELANE monoclonal antibodyHuman
GM-Tg-rg-T40332-Ab-1/ GM-Tg-rg-T40332-Ab-2Anti-Rat NE/ELANE monoclonal antibodyRat
GM-Tg-mg-T40332-Ab-1/ GM-Tg-mg-T40332-Ab-2Anti-Mouse NE/ELANE monoclonal antibodyMouse
GM-Tg-cynog-T40332-Ab-1/ GM-Tg-cynog-T40332-Ab-2Anti-Cynomolgus/ Rhesus macaque NE/ELANE monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T40332-Ab-1/ GM-Tg-felg-T40332-Ab-2Anti-Feline NE/ELANE monoclonal antibodyFeline
GM-Tg-cang-T40332-Ab-1/ GM-Tg-cang-T40332-Ab-2Anti-Canine NE/ELANE monoclonal antibodyCanine
GM-Tg-bovg-T40332-Ab-1/ GM-Tg-bovg-T40332-Ab-2Anti-Bovine NE/ELANE monoclonal antibodyBovine
GM-Tg-equg-T40332-Ab-1/ GM-Tg-equg-T40332-Ab-2Anti-Equine NE/ELANE monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T40332-Ab-1/ GM-Tg-hg-T40332-Ab-2; GM-Tg-rg-T40332-Ab-1/ GM-Tg-rg-T40332-Ab-2;
GM-Tg-mg-T40332-Ab-1/ GM-Tg-mg-T40332-Ab-2; GM-Tg-cynog-T40332-Ab-1/ GM-Tg-cynog-T40332-Ab-2;
GM-Tg-felg-T40332-Ab-1/ GM-Tg-felg-T40332-Ab-2; GM-Tg-cang-T40332-Ab-1/ GM-Tg-cang-T40332-Ab-2;
GM-Tg-bovg-T40332-Ab-1/ GM-Tg-bovg-T40332-Ab-2; GM-Tg-equg-T40332-Ab-1/ GM-Tg-equg-T40332-Ab-2
Products NameAnti-NE/ELANE monoclonal antibody
Formatmab
Target NameNE
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NE benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T40332-Ag-1Recombinant multi-species ELNE/ NE/ ELANE protein
    ORF Viral VectorpGMLP004544human ELANE Lentivirus plasmid
    ORF Viral VectorvGMLP004544human ELANE Lentivirus particle
    ORF Viral VectorpGMLPm002774mouse Elane Lentivirus plasmid
    ORF Viral VectorvGMLPm002774mouse Elane Lentivirus particle


    Target information

    Target IDGM-T40332
    Target NameNE
    Gene ID1991,50701,299606,106992354,442980,100301482,100126050,111774155
    Gene Symbol and SynonymsELA2,ELANE,F430011M15Rik,GE,HLE,HNE,NE,PMN-E,SCN1
    Uniprot AccessionP08246
    Uniprot Entry NameELNE_HUMAN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target
    DiseaseInterstitial cystitis (chronic)
    Gene EnsemblENSG00000197561
    Target ClassificationN/A

    The target: NE, gene name: ELANE, also named as ELA2, GE, HLE, HNE, NE, PMN-E, SCN1. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016].



    About Gmab

    GDU
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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.