Anti-HSPB1/ HSP20/ CMT2F monoclonal antibody
Anti-HSPB1/ HSP20/ CMT2F antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T39921-Ab-1/ GM-Tg-hg-T39921-Ab-2 | Anti-Human HSP20/HSPB1 monoclonal antibody | Human |
GM-Tg-rg-T39921-Ab-1/ GM-Tg-rg-T39921-Ab-2 | Anti-Rat HSP20/HSPB1 monoclonal antibody | Rat |
GM-Tg-mg-T39921-Ab-1/ GM-Tg-mg-T39921-Ab-2 | Anti-Mouse HSP20/HSPB1 monoclonal antibody | Mouse |
GM-Tg-cynog-T39921-Ab-1/ GM-Tg-cynog-T39921-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HSP20/HSPB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T39921-Ab-1/ GM-Tg-felg-T39921-Ab-2 | Anti-Feline HSP20/HSPB1 monoclonal antibody | Feline |
GM-Tg-cang-T39921-Ab-1/ GM-Tg-cang-T39921-Ab-2 | Anti-Canine HSP20/HSPB1 monoclonal antibody | Canine |
GM-Tg-bovg-T39921-Ab-1/ GM-Tg-bovg-T39921-Ab-2 | Anti-Bovine HSP20/HSPB1 monoclonal antibody | Bovine |
GM-Tg-equg-T39921-Ab-1/ GM-Tg-equg-T39921-Ab-2 | Anti-Equine HSP20/HSPB1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T39921-Ab-1/ GM-Tg-hg-T39921-Ab-2; GM-Tg-rg-T39921-Ab-1/ GM-Tg-rg-T39921-Ab-2; GM-Tg-mg-T39921-Ab-1/ GM-Tg-mg-T39921-Ab-2; GM-Tg-cynog-T39921-Ab-1/ GM-Tg-cynog-T39921-Ab-2; GM-Tg-felg-T39921-Ab-1/ GM-Tg-felg-T39921-Ab-2; GM-Tg-cang-T39921-Ab-1/ GM-Tg-cang-T39921-Ab-2; GM-Tg-bovg-T39921-Ab-1/ GM-Tg-bovg-T39921-Ab-2; GM-Tg-equg-T39921-Ab-1/ GM-Tg-equg-T39921-Ab-2 |
Products Name | Anti-HSP20/HSPB1 monoclonal antibody |
Format | mab |
Target Name | HSP20 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-HSP20 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species HSPB1/ HSP20/ CMT2F VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLV000837 | human HSPB1 Lentivirus plasmid |
ORF Viral Vector | pGMLV000322 | human HSPB1 Lentivirus plasmid |
ORF Viral Vector | vGMLV000837 | human HSPB1 Lentivirus particle |
ORF Viral Vector | vGMLV000322 | human HSPB1 Lentivirus particle |
ORF Viral Vector | pGMLPm001898 | mouse Hspb1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm001898 | mouse Hspb1 Lentivirus particle |
Target information
Target ID | GM-T39921 |
Target Name | HSP20 |
Gene ID | 3315,15507,24471,715615,403979,101084411,516099,100059763 |
Gene Symbol and Synonyms | 27kDa,CMT2F,HEL-S-102,HMN2B,HS.76067,Hsp25,HSP27,HSP28,HSPB1,SRP27 |
Uniprot Accession | P04792,P42930,P42929,Q3T149 |
Uniprot Entry Name | HSPB1_HUMAN,HSPB1_RAT,HSPB1_CANLF,HSPB1_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Prostate Cancer, Congenital occlusion of ureteropelvic junction, Renal clear cell carcinoma |
Gene Ensembl | ENSG00000106211 |
Target Classification | N/A |
The target: HSP20, gene name: HSPB1, also named as CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27. This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.