Anti-HSPB1/ HSP20/ CMT2F monoclonal antibody

Anti-HSPB1/ HSP20/ CMT2F antibody for FACS & in-vivo assay

Target products collectionGo to HSP20/HSPB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T39921-Ab-1/ GM-Tg-hg-T39921-Ab-2Anti-Human HSP20/HSPB1 monoclonal antibodyHuman
GM-Tg-rg-T39921-Ab-1/ GM-Tg-rg-T39921-Ab-2Anti-Rat HSP20/HSPB1 monoclonal antibodyRat
GM-Tg-mg-T39921-Ab-1/ GM-Tg-mg-T39921-Ab-2Anti-Mouse HSP20/HSPB1 monoclonal antibodyMouse
GM-Tg-cynog-T39921-Ab-1/ GM-Tg-cynog-T39921-Ab-2Anti-Cynomolgus/ Rhesus macaque HSP20/HSPB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T39921-Ab-1/ GM-Tg-felg-T39921-Ab-2Anti-Feline HSP20/HSPB1 monoclonal antibodyFeline
GM-Tg-cang-T39921-Ab-1/ GM-Tg-cang-T39921-Ab-2Anti-Canine HSP20/HSPB1 monoclonal antibodyCanine
GM-Tg-bovg-T39921-Ab-1/ GM-Tg-bovg-T39921-Ab-2Anti-Bovine HSP20/HSPB1 monoclonal antibodyBovine
GM-Tg-equg-T39921-Ab-1/ GM-Tg-equg-T39921-Ab-2Anti-Equine HSP20/HSPB1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T39921-Ab-1/ GM-Tg-hg-T39921-Ab-2; GM-Tg-rg-T39921-Ab-1/ GM-Tg-rg-T39921-Ab-2;
GM-Tg-mg-T39921-Ab-1/ GM-Tg-mg-T39921-Ab-2; GM-Tg-cynog-T39921-Ab-1/ GM-Tg-cynog-T39921-Ab-2;
GM-Tg-felg-T39921-Ab-1/ GM-Tg-felg-T39921-Ab-2; GM-Tg-cang-T39921-Ab-1/ GM-Tg-cang-T39921-Ab-2;
GM-Tg-bovg-T39921-Ab-1/ GM-Tg-bovg-T39921-Ab-2; GM-Tg-equg-T39921-Ab-1/ GM-Tg-equg-T39921-Ab-2
Products NameAnti-HSP20/HSPB1 monoclonal antibody
Formatmab
Target NameHSP20
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-HSP20 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species HSPB1/ HSP20/ CMT2F VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000837human HSPB1 Lentivirus plasmid
    ORF Viral VectorpGMLV000322human HSPB1 Lentivirus plasmid
    ORF Viral VectorvGMLV000837human HSPB1 Lentivirus particle
    ORF Viral VectorvGMLV000322human HSPB1 Lentivirus particle
    ORF Viral VectorpGMLPm001898mouse Hspb1 Lentivirus plasmid
    ORF Viral VectorvGMLPm001898mouse Hspb1 Lentivirus particle


    Target information

    Target IDGM-T39921
    Target NameHSP20
    Gene ID3315,15507,24471,715615,403979,101084411,516099,100059763
    Gene Symbol and Synonyms27kDa,CMT2F,HEL-S-102,HMN2B,HS.76067,Hsp25,HSP27,HSP28,HSPB1,SRP27
    Uniprot AccessionP04792,P42930,P42929,Q3T149
    Uniprot Entry NameHSPB1_HUMAN,HSPB1_RAT,HSPB1_CANLF,HSPB1_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseProstate Cancer, Congenital occlusion of ureteropelvic junction, Renal clear cell carcinoma
    Gene EnsemblENSG00000106211
    Target ClassificationN/A

    The target: HSP20, gene name: HSPB1, also named as CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27. This gene encodes a member of the small heat shock protein (HSP20) family of proteins. In response to environmental stress, the encoded protein translocates from the cytoplasm to the nucleus and functions as a molecular chaperone that promotes the correct folding of other proteins. This protein plays an important role in the differentiation of a wide variety of cell types. Expression of this gene is correlated with poor clinical outcome in multiple human cancers, and the encoded protein may promote cancer cell proliferation and metastasis, while protecting cancer cells from apoptosis. Mutations in this gene have been identified in human patients with Charcot-Marie-Tooth disease and distal hereditary motor neuropathy. [provided by RefSeq, Aug 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.