Anti-ACVL1/ ACVRL1/ ACVRLK1 monoclonal antibody

Anti-ACVL1/ ACVRL1/ ACVRLK1 antibody for FACS & in-vivo assay

Target products collectionGo to ACVRL1/ACVRL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T36959-Ab-1/ GM-Tg-hg-T36959-Ab-2Anti-Human ACVRL1 monoclonal antibodyHuman
GM-Tg-rg-T36959-Ab-1/ GM-Tg-rg-T36959-Ab-2Anti-Rat ACVRL1 monoclonal antibodyRat
GM-Tg-mg-T36959-Ab-1/ GM-Tg-mg-T36959-Ab-2Anti-Mouse ACVRL1 monoclonal antibodyMouse
GM-Tg-cynog-T36959-Ab-1/ GM-Tg-cynog-T36959-Ab-2Anti-Cynomolgus/ Rhesus macaque ACVRL1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T36959-Ab-1/ GM-Tg-felg-T36959-Ab-2Anti-Feline ACVRL1 monoclonal antibodyFeline
GM-Tg-cang-T36959-Ab-1/ GM-Tg-cang-T36959-Ab-2Anti-Canine ACVRL1 monoclonal antibodyCanine
GM-Tg-bovg-T36959-Ab-1/ GM-Tg-bovg-T36959-Ab-2Anti-Bovine ACVRL1 monoclonal antibodyBovine
GM-Tg-equg-T36959-Ab-1/ GM-Tg-equg-T36959-Ab-2Anti-Equine ACVRL1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T36959-Ab-1/ GM-Tg-hg-T36959-Ab-2; GM-Tg-rg-T36959-Ab-1/ GM-Tg-rg-T36959-Ab-2;
GM-Tg-mg-T36959-Ab-1/ GM-Tg-mg-T36959-Ab-2; GM-Tg-cynog-T36959-Ab-1/ GM-Tg-cynog-T36959-Ab-2;
GM-Tg-felg-T36959-Ab-1/ GM-Tg-felg-T36959-Ab-2; GM-Tg-cang-T36959-Ab-1/ GM-Tg-cang-T36959-Ab-2;
GM-Tg-bovg-T36959-Ab-1/ GM-Tg-bovg-T36959-Ab-2; GM-Tg-equg-T36959-Ab-1/ GM-Tg-equg-T36959-Ab-2
Products NameAnti-ACVRL1 monoclonal antibody
Formatmab
Target NameACVRL1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ACVRL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-032Pre-Made Ascrinvacumab biosimilar, Whole mAb, Anti-ACVRL1 Antibody: Anti-ACVRLK1/ALK-1/ALK1/HHT/HHT2/ORW2/SKR3/TSR-I therapeutic antibody
    Target AntigenProducts DevelopingMulti-species ACVL1/ ACVRL1/ ACVRLK1 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T36959-Ag-1activin A receptor type II-like 1 (ACVRL1) protein
    ORF Viral VectorpGMLPm004968mouse Acvrl1 Lentivirus plasmid
    ORF Viral VectorvGMLPm004968mouse Acvrl1 Lentivirus particle


    Target information

    Target IDGM-T36959
    Target NameACVRL1
    Gene ID94,11482,25237,696471,477603,101097406,534536,100061313
    Gene Symbol and SynonymsACVRL1,ACVRLK1,ALK-1,ALK1,HHT,HHT2,ORW2,R-3,R3,SETHKIR,SKR3,TSR-I
    Uniprot AccessionP37023,P80203
    Uniprot Entry NameACVL1_HUMAN,ACVL1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000139567
    Target ClassificationKinase, Tumor-associated antigen (TAA)

    The target: ACVRL1, gene name: ACVRL1, also named as ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.