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Anti-PADI3 monoclonal antibody
Pre-made anti-PADI3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PADI3/PADI3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T36612-Ab-1/ GM-Tg-hg-T36612-Ab-2 | Anti-Human PADI3 monoclonal antibody | Human |
| GM-Tg-rg-T36612-Ab-1/ GM-Tg-rg-T36612-Ab-2 | Anti-Rat PADI3 monoclonal antibody | Rat |
| GM-Tg-mg-T36612-Ab-1/ GM-Tg-mg-T36612-Ab-2 | Anti-Mouse PADI3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T36612-Ab-1/ GM-Tg-cynog-T36612-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PADI3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T36612-Ab-1/ GM-Tg-felg-T36612-Ab-2 | Anti-Feline PADI3 monoclonal antibody | Feline |
| GM-Tg-cang-T36612-Ab-1/ GM-Tg-cang-T36612-Ab-2 | Anti-Canine PADI3 monoclonal antibody | Canine |
| GM-Tg-bovg-T36612-Ab-1/ GM-Tg-bovg-T36612-Ab-2 | Anti-Bovine PADI3 monoclonal antibody | Bovine |
| GM-Tg-equg-T36612-Ab-1/ GM-Tg-equg-T36612-Ab-2 | Anti-Equine PADI3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T36612-Ab-1/ GM-Tg-hg-T36612-Ab-2; GM-Tg-rg-T36612-Ab-1/ GM-Tg-rg-T36612-Ab-2; GM-Tg-mg-T36612-Ab-1/ GM-Tg-mg-T36612-Ab-2; GM-Tg-cynog-T36612-Ab-1/ GM-Tg-cynog-T36612-Ab-2; GM-Tg-felg-T36612-Ab-1/ GM-Tg-felg-T36612-Ab-2; GM-Tg-cang-T36612-Ab-1/ GM-Tg-cang-T36612-Ab-2; GM-Tg-bovg-T36612-Ab-1/ GM-Tg-bovg-T36612-Ab-2; GM-Tg-equg-T36612-Ab-1/ GM-Tg-equg-T36612-Ab-2 |
| Products Name | Anti-PADI3 monoclonal antibody |
| Format | mab |
| Target Name | PADI3 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PADI3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T36612-Ag-1 | Recombinant multi-species PADI3/ PAD3/ PDI3 protein |
| ORF Viral Vector | pGMLV000112 | human PADI3 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000112 | human PADI3 Lentivirus particle |
| ORF Viral Vector | pGMLP000203 | human PADI3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000203 | human PADI3 Lentivirus particle |
Target information
| Target ID | GM-T36612 |
| Target Name | PADI3 |
| Gene ID | 51702,18601,29520,700560,478216,101085813,508160,100049897 |
| Gene Symbol and Synonyms | mKIAA4171,PAD3,PADI3,PDI3,UHS1 |
| Uniprot Accession | Q9ULW8,P70708 |
| Uniprot Entry Name | PADI3_HUMAN,PADI3_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000142619 |
| Target Classification | N/A |
The target: PADI3, gene name: PADI3, also named as PAD3, PDI3, UHS1. This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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