Anti-PAR1/ F2R/ CF2R monoclonal antibody

Anti-PAR1/ F2R/ CF2R antibody for FACS & in-vivo assay

Target products collectionGo to F2R/F2R products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T36483-Ab-1/ GM-Tg-hg-T36483-Ab-2Anti-Human F2R monoclonal antibodyHuman
GM-Tg-rg-T36483-Ab-1/ GM-Tg-rg-T36483-Ab-2Anti-Rat F2R monoclonal antibodyRat
GM-Tg-mg-T36483-Ab-1/ GM-Tg-mg-T36483-Ab-2Anti-Mouse F2R monoclonal antibodyMouse
GM-Tg-cynog-T36483-Ab-1/ GM-Tg-cynog-T36483-Ab-2Anti-Cynomolgus/ Rhesus macaque F2R monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T36483-Ab-1/ GM-Tg-felg-T36483-Ab-2Anti-Feline F2R monoclonal antibodyFeline
GM-Tg-cang-T36483-Ab-1/ GM-Tg-cang-T36483-Ab-2Anti-Canine F2R monoclonal antibodyCanine
GM-Tg-bovg-T36483-Ab-1/ GM-Tg-bovg-T36483-Ab-2Anti-Bovine F2R monoclonal antibodyBovine
GM-Tg-equg-T36483-Ab-1/ GM-Tg-equg-T36483-Ab-2Anti-Equine F2R monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T36483-Ab-1/ GM-Tg-hg-T36483-Ab-2; GM-Tg-rg-T36483-Ab-1/ GM-Tg-rg-T36483-Ab-2;
GM-Tg-mg-T36483-Ab-1/ GM-Tg-mg-T36483-Ab-2; GM-Tg-cynog-T36483-Ab-1/ GM-Tg-cynog-T36483-Ab-2;
GM-Tg-felg-T36483-Ab-1/ GM-Tg-felg-T36483-Ab-2; GM-Tg-cang-T36483-Ab-1/ GM-Tg-cang-T36483-Ab-2;
GM-Tg-bovg-T36483-Ab-1/ GM-Tg-bovg-T36483-Ab-2; GM-Tg-equg-T36483-Ab-1/ GM-Tg-equg-T36483-Ab-2
Products NameAnti-F2R monoclonal antibody
Formatmab
Target NameF2R
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-F2R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PAR1/ F2R/ CF2R VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP003683human F2R Lentivirus particle
    ORF Viral VectorpGMLP003683human F2R Lentivirus plasmid
    ORF Viral VectorpGMLPm003837mouse F2r Lentivirus plasmid
    ORF Viral VectorvGMLPm003837mouse F2r Lentivirus particle


    Target information

    Target IDGM-T36483
    Target NameF2R
    Gene ID2149,14062,25439,707370,488942,101100861,526585,100073278
    Gene Symbol and SynonymsCF2R,F2R,HTR,PAR-1,PAR1,ThrR,TR,TRGPC
    Uniprot AccessionP25116,P26824,A7YY44
    Uniprot Entry NamePAR1_HUMAN,PAR1_RAT,PAR1_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000181104
    Target ClassificationN/A

    The target: F2R, gene name: F2R, also named as CF2R, HTR, PAR-1, PAR1, TR. Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.