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Anti-12-LOX monoclonal antibody
Pre-made anti-12-LOX monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to 12-LOX/ALOX12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T35527-Ab-1/ GM-Tg-hg-T35527-Ab-2 | Anti-Human 12-LOX/ALOX12 monoclonal antibody | Human |
| GM-Tg-rg-T35527-Ab-1/ GM-Tg-rg-T35527-Ab-2 | Anti-Rat 12-LOX/ALOX12 monoclonal antibody | Rat |
| GM-Tg-mg-T35527-Ab-1/ GM-Tg-mg-T35527-Ab-2 | Anti-Mouse 12-LOX/ALOX12 monoclonal antibody | Mouse |
| GM-Tg-cynog-T35527-Ab-1/ GM-Tg-cynog-T35527-Ab-2 | Anti-Cynomolgus/ Rhesus macaque 12-LOX/ALOX12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T35527-Ab-1/ GM-Tg-felg-T35527-Ab-2 | Anti-Feline 12-LOX/ALOX12 monoclonal antibody | Feline |
| GM-Tg-cang-T35527-Ab-1/ GM-Tg-cang-T35527-Ab-2 | Anti-Canine 12-LOX/ALOX12 monoclonal antibody | Canine |
| GM-Tg-bovg-T35527-Ab-1/ GM-Tg-bovg-T35527-Ab-2 | Anti-Bovine 12-LOX/ALOX12 monoclonal antibody | Bovine |
| GM-Tg-equg-T35527-Ab-1/ GM-Tg-equg-T35527-Ab-2 | Anti-Equine 12-LOX/ALOX12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T35527-Ab-1/ GM-Tg-hg-T35527-Ab-2; GM-Tg-rg-T35527-Ab-1/ GM-Tg-rg-T35527-Ab-2; GM-Tg-mg-T35527-Ab-1/ GM-Tg-mg-T35527-Ab-2; GM-Tg-cynog-T35527-Ab-1/ GM-Tg-cynog-T35527-Ab-2; GM-Tg-felg-T35527-Ab-1/ GM-Tg-felg-T35527-Ab-2; GM-Tg-cang-T35527-Ab-1/ GM-Tg-cang-T35527-Ab-2; GM-Tg-bovg-T35527-Ab-1/ GM-Tg-bovg-T35527-Ab-2; GM-Tg-equg-T35527-Ab-1/ GM-Tg-equg-T35527-Ab-2 |
| Products Name | Anti-12-LOX/ALOX12 monoclonal antibody |
| Format | mab |
| Target Name | 12-LOX |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-12-LOX monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T35527-Ag-1 | Recombinant multi-species LOX12/ 12-LOX/ ALOX12 protein |
| ORF Viral Vector | pGMAD000199 | mouse Alox12 Adenovirus plasmid |
| ORF Viral Vector | vGMAD000199 | mouse Alox12 Adenovirus particle |
Target information
| Target ID | GM-T35527 |
| Target Name | 12-LOX |
| Gene ID | 239,11684,287454,713748,407169 |
| Gene Symbol and Synonyms | 12-LO,12-LOX,12S-LOX,9930022G08Rik,ALOX12,Alox12p,LOG12,P-12LO |
| Uniprot Accession | P18054,F1LQ70 |
| Uniprot Entry Name | LOX12_HUMAN,LOX12_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000108839 |
| Target Classification | N/A |
The target: 12-LOX, gene name: ALOX12, also named as 12-LOX, 12S-LOX, LOG12. This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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