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Anti-IBP3/ IGFBP3/ BP-53 functional antibody
Anti-IBP3/ IGFBP3/ BP-53 functional antibody for cell culture, ELISA & in-vivo assay
Go to IGFBP3/IGFBP3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T33455-Ab-1/ GM-Tg-hg-T33455-Ab-2 | Anti-Human IGFBP3 monoclonal antibody | Human |
| GM-Tg-rg-T33455-Ab-1/ GM-Tg-rg-T33455-Ab-2 | Anti-Rat IGFBP3 monoclonal antibody | Rat |
| GM-Tg-mg-T33455-Ab-1/ GM-Tg-mg-T33455-Ab-2 | Anti-Mouse IGFBP3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T33455-Ab-1/ GM-Tg-cynog-T33455-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IGFBP3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T33455-Ab-1/ GM-Tg-felg-T33455-Ab-2 | Anti-Feline IGFBP3 monoclonal antibody | Feline |
| GM-Tg-cang-T33455-Ab-1/ GM-Tg-cang-T33455-Ab-2 | Anti-Canine IGFBP3 monoclonal antibody | Canine |
| GM-Tg-bovg-T33455-Ab-1/ GM-Tg-bovg-T33455-Ab-2 | Anti-Bovine IGFBP3 monoclonal antibody | Bovine |
| GM-Tg-equg-T33455-Ab-1/ GM-Tg-equg-T33455-Ab-2 | Anti-Equine IGFBP3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T33455-Ab-1/ GM-Tg-hg-T33455-Ab-2; GM-Tg-rg-T33455-Ab-1/ GM-Tg-rg-T33455-Ab-2; GM-Tg-mg-T33455-Ab-1/ GM-Tg-mg-T33455-Ab-2; GM-Tg-cynog-T33455-Ab-1/ GM-Tg-cynog-T33455-Ab-2; GM-Tg-felg-T33455-Ab-1/ GM-Tg-felg-T33455-Ab-2; GM-Tg-cang-T33455-Ab-1/ GM-Tg-cang-T33455-Ab-2; GM-Tg-bovg-T33455-Ab-1/ GM-Tg-bovg-T33455-Ab-2; GM-Tg-equg-T33455-Ab-1/ GM-Tg-equg-T33455-Ab-2 |
| Products Name | Anti-IGFBP3 monoclonal antibody |
| Format | mab |
| Target Name | IGFBP3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IGFBP3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T33455-Ag-1 | Recombinant multi-species IBP3/ IGFBP3/ BP-53 protein |
| Cytokine | GM-Tg-g-T33455-Ag-1 | insulin-like growth factor binding protein 3 (IGFBP3) protein |
| ORF Viral Vector | vGMLP004768 | human IGFBP3 Lentivirus particle |
| ORF Viral Vector | pGMLP004768 | human IGFBP3 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm004503 | mouse Igfbp3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004503 | mouse Igfbp3 Lentivirus particle |
Target information
| Target ID | GM-T33455 |
| Target Name | IGFBP3 |
| Gene ID | 3486,16009,24484,696868,100855619,101080442,282261,100034155 |
| Gene Symbol and Synonyms | BP-53,IBP3,IGF-BP3,IGFBP-3,IGFBP3,IGgfbp3 |
| Uniprot Accession | P17936,P15473,P20959 |
| Uniprot Entry Name | IBP3_HUMAN,IBP3_RAT,IBP3_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Ovary Cancer |
| Gene Ensembl | ENSG00000146674 |
| Target Classification | N/A |
The target: IGFBP3, gene name: IGFBP3, also named as BP-53, IBP3. This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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