Anti-GDF15/ GDF-15/ MIC-1 functional antibody

Anti-GDF15/ GDF-15/ MIC-1 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to GDF15/GDF15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T33245-Ab-1/ GM-Tg-hg-T33245-Ab-2Anti-Human GDF15 monoclonal antibodyHuman
GM-Tg-rg-T33245-Ab-1/ GM-Tg-rg-T33245-Ab-2Anti-Rat GDF15 monoclonal antibodyRat
GM-Tg-mg-T33245-Ab-1/ GM-Tg-mg-T33245-Ab-2Anti-Mouse GDF15 monoclonal antibodyMouse
GM-Tg-cynog-T33245-Ab-1/ GM-Tg-cynog-T33245-Ab-2Anti-Cynomolgus/ Rhesus macaque GDF15 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T33245-Ab-1/ GM-Tg-felg-T33245-Ab-2Anti-Feline GDF15 monoclonal antibodyFeline
GM-Tg-cang-T33245-Ab-1/ GM-Tg-cang-T33245-Ab-2Anti-Canine GDF15 monoclonal antibodyCanine
GM-Tg-bovg-T33245-Ab-1/ GM-Tg-bovg-T33245-Ab-2Anti-Bovine GDF15 monoclonal antibodyBovine
GM-Tg-equg-T33245-Ab-1/ GM-Tg-equg-T33245-Ab-2Anti-Equine GDF15 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T33245-Ab-1/ GM-Tg-hg-T33245-Ab-2; GM-Tg-rg-T33245-Ab-1/ GM-Tg-rg-T33245-Ab-2;
GM-Tg-mg-T33245-Ab-1/ GM-Tg-mg-T33245-Ab-2; GM-Tg-cynog-T33245-Ab-1/ GM-Tg-cynog-T33245-Ab-2;
GM-Tg-felg-T33245-Ab-1/ GM-Tg-felg-T33245-Ab-2; GM-Tg-cang-T33245-Ab-1/ GM-Tg-cang-T33245-Ab-2;
GM-Tg-bovg-T33245-Ab-1/ GM-Tg-bovg-T33245-Ab-2; GM-Tg-equg-T33245-Ab-1/ GM-Tg-equg-T33245-Ab-2
Products NameAnti-GDF15 monoclonal antibody
Formatmab
Target NameGDF15
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GDF15 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-451Pre-Made Ponsegromab biosimilar, Whole mAb, Anti-GDF15 Antibody: Anti-GDF-15/MIC-1/MIC1/NAG-1/PDF/PLAB/PTGFB therapeutic antibody
    Target AntigenGM-Tg-g-T33245-Ag-1Recombinant multi-species GDF15/ GDF-15/ MIC-1 protein
    CytokineGM-Tg-g-T33245-Ag-1growth differentiation factor 15 (GDF15) protein
    ORF Viral VectorvGMLP000446human GDF15 Lentivirus particle
    ORF Viral VectorpGMLP000446human GDF15 Lentivirus plasmid
    ORF Viral VectorpGMLPm004533mouse Gdf15 Lentivirus plasmid
    ORF Viral VectorvGMLPm004533mouse Gdf15 Lentivirus particle


    Target information

    Target IDGM-T33245
    Target NameGDF15
    Gene ID9518,23886,29455,719466,484822,101086633,618677,111769675
    Gene Symbol and SynonymsGDF-15,GDF15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB,SBF
    Uniprot AccessionQ99988,Q9Z0J6
    Uniprot Entry NameGDF15_HUMAN,GDF15_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Diagnostics Biomarker, INN Index, Cytokine Target
    DiseaseOvary Cancer
    Gene EnsemblENSG00000130513
    Target ClassificationN/A

    The target: GDF15, gene name: GDF15, also named as GDF-15, MIC-1, MIC1, NAG-1, PDF, PLAB, PTGFB. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress response program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Aug 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.