Anti-IL6/ BSF-2/ BSF2 functional antibody

Anti-IL6/ BSF-2/ BSF2 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to IL6/IL6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T32578-Ab-1/ GM-Tg-hg-T32578-Ab-2Anti-Human IL6 monoclonal antibodyHuman
GM-Tg-rg-T32578-Ab-1/ GM-Tg-rg-T32578-Ab-2Anti-Rat IL6 monoclonal antibodyRat
GM-Tg-mg-T32578-Ab-1/ GM-Tg-mg-T32578-Ab-2Anti-Mouse IL6 monoclonal antibodyMouse
GM-Tg-cynog-T32578-Ab-1/ GM-Tg-cynog-T32578-Ab-2Anti-Cynomolgus/ Rhesus macaque IL6 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T32578-Ab-1/ GM-Tg-felg-T32578-Ab-2Anti-Feline IL6 monoclonal antibodyFeline
GM-Tg-cang-T32578-Ab-1/ GM-Tg-cang-T32578-Ab-2Anti-Canine IL6 monoclonal antibodyCanine
GM-Tg-bovg-T32578-Ab-1/ GM-Tg-bovg-T32578-Ab-2Anti-Bovine IL6 monoclonal antibodyBovine
GM-Tg-equg-T32578-Ab-1/ GM-Tg-equg-T32578-Ab-2Anti-Equine IL6 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T32578-Ab-1/ GM-Tg-hg-T32578-Ab-2; GM-Tg-rg-T32578-Ab-1/ GM-Tg-rg-T32578-Ab-2;
GM-Tg-mg-T32578-Ab-1/ GM-Tg-mg-T32578-Ab-2; GM-Tg-cynog-T32578-Ab-1/ GM-Tg-cynog-T32578-Ab-2;
GM-Tg-felg-T32578-Ab-1/ GM-Tg-felg-T32578-Ab-2; GM-Tg-cang-T32578-Ab-1/ GM-Tg-cang-T32578-Ab-2;
GM-Tg-bovg-T32578-Ab-1/ GM-Tg-bovg-T32578-Ab-2; GM-Tg-equg-T32578-Ab-1/ GM-Tg-equg-T32578-Ab-2
Products NameAnti-IL6 monoclonal antibody
Formatmab
Target NameIL6
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL6 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-932Pre-Made Olamkicept Biosimilar, Fusion Protein targeting IL6 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting BSF-2/BSF2/CDF/HGF/HSF/IFN-beta-2/IFNB2/IL-6
    BiosimilarGMP-Bios-ab-646Pre-Made Ziltivekimab biosimilar, Whole mAb, Anti-IL6 Antibody: Anti-BSF-2/BSF2/CDF/HGF/HSF/IFN-beta-2/IFNB2/IL-6 therapeutic antibody
    BiosimilarGMP-Bios-ab-520Pre-Made Siltuximab biosimilar, Whole mAb, Anti-IL6 Antibody: Anti-BSF-2/BSF2/CDF/HGF/HSF/IFN-beta-2/IFNB2/IL-6 therapeutic antibody
    BiosimilarGMP-Bios-INN-831Pre-Made Elsilimomab Biosimilar, Whole Mab, Anti-Il6 Antibody: Anti-BSF-2/BSF2/CDF/HGF/HSF/IFN-beta-2/IFNB2/IL-6 therapeutic antibody
    BiosimilarGMP-Bios-ab-525Pre-Made Sirukumab biosimilar, Whole mAb, Anti-IL6 Antibody: Anti-BSF-2/BSF2/CDF/HGF/HSF/IFN-beta-2/IFNB2/IL-6 therapeutic antibody
    BiosimilarGMP-Bios-ab-110Pre-Made Clazakizumab biosimilar, Whole mAb, Anti-IL6 Antibody: Anti-BSF-2/BSF2/CDF/HGF/HSF/IFN-beta-2/IFNB2/IL-6 therapeutic antibody
    BiosimilarGMP-Bios-ab-397Pre-Made Olokizumab biosimilar, Whole mAb, Anti-IL6 Antibody: Anti-BSF-2/BSF2/CDF/HGF/HSF/IFN-beta-2/IFNB2/IL-6 therapeutic antibody
    Target AntigenGM-Tg-g-T32578-Ag-1Recombinant multi-species IL6/ BSF-2/ BSF2 protein
    CytokineGM-Tg-g-T32578-Ag-1Interleukin 6 (IL6) protein
    ORF Viral VectorvGMLP000469human IL6 Lentivirus particle
    ORF Viral VectorpGMLP000469human IL6 Lentivirus plasmid
    ORF Viral VectorpGMAP000315Human IL6 Adenovirus plasmid
    ORF Viral VectorvGMAP000315Human IL6 Adenovirus particle
    ORF Viral VectorpGMLV000053mouse Il6 Lentivirus plasmid
    ORF Viral VectorvGMLV000053mouse Il6 Lentivirus particle


    Target information

    Target IDGM-T32578
    Target NameIL6
    Gene ID3569,16193,24498,705819,403985,493687,280826,100034196
    Gene Symbol and SynonymsBSF-2,BSF2,CDF,HGF,HSF,IFN-beta-2,IFNB2,IL-6,IL6,ILg6
    Uniprot AccessionP05231,P20607,P51494,P41323,P41683,P26892,Q95181
    Uniprot Entry NameIL6_HUMAN,IL6_MACMU,IL6_RAT,IL6_FELCA,IL6_CANLF,IL6_BOVIN,IL6_HORSE
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Diagnostics Biomarker, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseUrolithiasis, Acute kidney failure, Diabetic Nephropathy, Interstitial cystitis (chronic), Malignant neoplasm of bladder, Overactive bladder, Type 1 diabetes mellitus, Urinary bladder urothelial carcinoma, Urinary Tract Infection
    Gene EnsemblENSG00000136244
    Target ClassificationCheckpoint-Immuno Oncology

    The target: IL6, gene name: IL6, also named as BSF-2, BSF2, CDF, HGF, HSF, IFN-beta-2, IFNB2, IL-6. This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.