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Anti-FGF2/ BFGF/ FGF-2 functional antibody
Anti-FGF2/ BFGF/ FGF-2 functional antibody for cell culture, ELISA & in-vivo assay
Go to FGF2/FGF2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T31621-Ab-1/ GM-Tg-hg-T31621-Ab-2 | Anti-Human FGF2 monoclonal antibody | Human |
| GM-Tg-rg-T31621-Ab-1/ GM-Tg-rg-T31621-Ab-2 | Anti-Rat FGF2 monoclonal antibody | Rat |
| GM-Tg-mg-T31621-Ab-1/ GM-Tg-mg-T31621-Ab-2 | Anti-Mouse FGF2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T31621-Ab-1/ GM-Tg-cynog-T31621-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FGF2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T31621-Ab-1/ GM-Tg-felg-T31621-Ab-2 | Anti-Feline FGF2 monoclonal antibody | Feline |
| GM-Tg-cang-T31621-Ab-1/ GM-Tg-cang-T31621-Ab-2 | Anti-Canine FGF2 monoclonal antibody | Canine |
| GM-Tg-bovg-T31621-Ab-1/ GM-Tg-bovg-T31621-Ab-2 | Anti-Bovine FGF2 monoclonal antibody | Bovine |
| GM-Tg-equg-T31621-Ab-1/ GM-Tg-equg-T31621-Ab-2 | Anti-Equine FGF2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T31621-Ab-1/ GM-Tg-hg-T31621-Ab-2; GM-Tg-rg-T31621-Ab-1/ GM-Tg-rg-T31621-Ab-2; GM-Tg-mg-T31621-Ab-1/ GM-Tg-mg-T31621-Ab-2; GM-Tg-cynog-T31621-Ab-1/ GM-Tg-cynog-T31621-Ab-2; GM-Tg-felg-T31621-Ab-1/ GM-Tg-felg-T31621-Ab-2; GM-Tg-cang-T31621-Ab-1/ GM-Tg-cang-T31621-Ab-2; GM-Tg-bovg-T31621-Ab-1/ GM-Tg-bovg-T31621-Ab-2; GM-Tg-equg-T31621-Ab-1/ GM-Tg-equg-T31621-Ab-2 |
| Products Name | Anti-FGF2 monoclonal antibody |
| Format | mab |
| Target Name | FGF2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FGF2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-INN-820 | Pre-Made Eflimrufusp Alfa Biosimilar, Fusion Protein targeting FGF2 fused with human IGHG1 Fc (Fragment constant): Recombinant therapeutic protein targeting BFGF/FGF-2/FGFB/HBGF-2 |
| Biosimilar | GMP-Bios-INN-969 | Pre-Made Recifercept biosimilar, Recombinant Protein: Recombinant therapeutic protein targeting FGF |
| Target Antigen | GM-Tg-g-T31621-Ag-1 | Recombinant multi-species FGF2/ BFGF/ FGF-2 protein |
| Cytokine | GM-Tg-g-T31621-Ag-1 | fibroblast growth factor 2 (basic) (FGF2) protein |
| ORF Viral Vector | vGMLV000801 | human FGF2 Lentivirus particle |
| ORF Viral Vector | vGMAD000136 | human FGF2 Adenovirus particle |
| ORF Viral Vector | pGMAD000136 | human FGF2 Adenovirus plasmid |
| ORF Viral Vector | pGMLV000801 | human FGF2 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000296 | rat Fgf2 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000253 | mouse Fgf2 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000296 | rat Fgf2 Adenovirus particle |
| ORF Viral Vector | vGMLPm000253 | mouse Fgf2 Lentivirus particle |
Target information
| Target ID | GM-T31621 |
| Target Name | FGF2 |
| Gene ID | 2247,14173,54250,574136,403857,100135772,281161,100033955 |
| Gene Symbol and Synonyms | BFGF,FGF-2,FGF2,Fgf2a,FGFB,HBGF-2 |
| Uniprot Accession | P09038,P13109,P03969 |
| Uniprot Entry Name | FGF2_HUMAN,FGF2_RAT,FGF2_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000138685 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: FGF2, gene name: FGF2, also named as BFGF, FGF-2, FGFB, HBGF-2. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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