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Anti-INGR2/ IFNGR2/ AF-1 monoclonal antibody
Anti-INGR2/ IFNGR2/ AF-1 antibody for FACS & in-vivo assay
Go to IFNGR2/IFNGR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T30284-Ab-1/ GM-Tg-hg-T30284-Ab-2 | Anti-Human IFNGR2 monoclonal antibody | Human |
| GM-Tg-rg-T30284-Ab-1/ GM-Tg-rg-T30284-Ab-2 | Anti-Rat IFNGR2 monoclonal antibody | Rat |
| GM-Tg-mg-T30284-Ab-1/ GM-Tg-mg-T30284-Ab-2 | Anti-Mouse IFNGR2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T30284-Ab-1/ GM-Tg-cynog-T30284-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IFNGR2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T30284-Ab-1/ GM-Tg-felg-T30284-Ab-2 | Anti-Feline IFNGR2 monoclonal antibody | Feline |
| GM-Tg-cang-T30284-Ab-1/ GM-Tg-cang-T30284-Ab-2 | Anti-Canine IFNGR2 monoclonal antibody | Canine |
| GM-Tg-bovg-T30284-Ab-1/ GM-Tg-bovg-T30284-Ab-2 | Anti-Bovine IFNGR2 monoclonal antibody | Bovine |
| GM-Tg-equg-T30284-Ab-1/ GM-Tg-equg-T30284-Ab-2 | Anti-Equine IFNGR2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T30284-Ab-1/ GM-Tg-hg-T30284-Ab-2; GM-Tg-rg-T30284-Ab-1/ GM-Tg-rg-T30284-Ab-2; GM-Tg-mg-T30284-Ab-1/ GM-Tg-mg-T30284-Ab-2; GM-Tg-cynog-T30284-Ab-1/ GM-Tg-cynog-T30284-Ab-2; GM-Tg-felg-T30284-Ab-1/ GM-Tg-felg-T30284-Ab-2; GM-Tg-cang-T30284-Ab-1/ GM-Tg-cang-T30284-Ab-2; GM-Tg-bovg-T30284-Ab-1/ GM-Tg-bovg-T30284-Ab-2; GM-Tg-equg-T30284-Ab-1/ GM-Tg-equg-T30284-Ab-2 |
| Products Name | Anti-IFNGR2 monoclonal antibody |
| Format | mab |
| Target Name | IFNGR2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IFNGR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species INGR2/ IFNGR2/ AF-1 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T30284-Ag-1 | interferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2) protein |
| ORF Viral Vector | pGMLPm000646 | mouse Ifngr2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000646 | mouse Ifngr2 Lentivirus particle |
Target information
| Target ID | GM-T30284 |
| Target Name | IFNGR2 |
| Gene ID | 3460,15980,360697,699489,487739,101092286,514889,100063333 |
| Gene Symbol and Synonyms | AF-1,IFGR2,Ifgt,IFNGR2,IFNGT1,IMD28 |
| Uniprot Accession | P38484 |
| Uniprot Entry Name | INGR2_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000159128 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IFNGR2, gene name: IFNGR2, also named as AF-1, IFGR2, IFNGT1, IMD28. This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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