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Anti-TK1 monoclonal antibody
Pre-made anti-TK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to TK1/TK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T30081-Ab-1/ GM-Tg-hg-T30081-Ab-2 | Anti-Human TK1 monoclonal antibody | Human |
| GM-Tg-rg-T30081-Ab-1/ GM-Tg-rg-T30081-Ab-2 | Anti-Rat TK1 monoclonal antibody | Rat |
| GM-Tg-mg-T30081-Ab-1/ GM-Tg-mg-T30081-Ab-2 | Anti-Mouse TK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T30081-Ab-1/ GM-Tg-cynog-T30081-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T30081-Ab-1/ GM-Tg-felg-T30081-Ab-2 | Anti-Feline TK1 monoclonal antibody | Feline |
| GM-Tg-cang-T30081-Ab-1/ GM-Tg-cang-T30081-Ab-2 | Anti-Canine TK1 monoclonal antibody | Canine |
| GM-Tg-bovg-T30081-Ab-1/ GM-Tg-bovg-T30081-Ab-2 | Anti-Bovine TK1 monoclonal antibody | Bovine |
| GM-Tg-equg-T30081-Ab-1/ GM-Tg-equg-T30081-Ab-2 | Anti-Equine TK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T30081-Ab-1/ GM-Tg-hg-T30081-Ab-2; GM-Tg-rg-T30081-Ab-1/ GM-Tg-rg-T30081-Ab-2; GM-Tg-mg-T30081-Ab-1/ GM-Tg-mg-T30081-Ab-2; GM-Tg-cynog-T30081-Ab-1/ GM-Tg-cynog-T30081-Ab-2; GM-Tg-felg-T30081-Ab-1/ GM-Tg-felg-T30081-Ab-2; GM-Tg-cang-T30081-Ab-1/ GM-Tg-cang-T30081-Ab-2; GM-Tg-bovg-T30081-Ab-1/ GM-Tg-bovg-T30081-Ab-2; GM-Tg-equg-T30081-Ab-1/ GM-Tg-equg-T30081-Ab-2 |
| Products Name | Anti-TK1 monoclonal antibody |
| Format | mab |
| Target Name | TK1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-TK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T30081-Ag-1 | Recombinant multi-species KITH/ TK1/ TK2 protein |
| ORF Viral Vector | pGMLPm000573 | mouse Tk1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000573 | mouse Tk1 Lentivirus particle |
Target information
| Target ID | GM-T30081 |
| Target Name | TK1 |
| Gene ID | 7083,21877,24834,709403,100855947,101101270,504652,100057908 |
| Gene Symbol and Synonyms | D530002A18Rik,Tk,Tk-1,TK1,Tk1a,Tk1b,TK2 |
| Uniprot Accession | P04183,P27158,A5D7R8 |
| Uniprot Entry Name | KITH_HUMAN,KITH_RAT,KITH_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target, Diagnostics Biomarker, Immuno-oncology Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000167900 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TK1, gene name: TK1, also named as TK2. The protein encoded by this gene is a cytosolic enzyme that catalyzes the addition of a gamma-phosphate group to thymidine. This creates d™P and is the first step in the biosynthesis of dTTP, which is one component required for DNA replication. The encoded protein, whose levels fluctuate depending on the cell cycle stage, can act as a low activity dimer or a high activity tetramer. High levels of this protein have been used as a biomarker for diagnosing and categorizing many types of cancers. [provided by RefSeq, Oct 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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