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Anti-STC1/ STC functional antibody
Anti-STC1/ STC functional antibody for cell culture, ELISA & in-vivo assay
Go to STC1/STC1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T30035-Ab-1/ GM-Tg-hg-T30035-Ab-2 | Anti-Human STC1 monoclonal antibody | Human |
| GM-Tg-rg-T30035-Ab-1/ GM-Tg-rg-T30035-Ab-2 | Anti-Rat STC1 monoclonal antibody | Rat |
| GM-Tg-mg-T30035-Ab-1/ GM-Tg-mg-T30035-Ab-2 | Anti-Mouse STC1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T30035-Ab-1/ GM-Tg-cynog-T30035-Ab-2 | Anti-Cynomolgus/ Rhesus macaque STC1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T30035-Ab-1/ GM-Tg-felg-T30035-Ab-2 | Anti-Feline STC1 monoclonal antibody | Feline |
| GM-Tg-cang-T30035-Ab-1/ GM-Tg-cang-T30035-Ab-2 | Anti-Canine STC1 monoclonal antibody | Canine |
| GM-Tg-bovg-T30035-Ab-1/ GM-Tg-bovg-T30035-Ab-2 | Anti-Bovine STC1 monoclonal antibody | Bovine |
| GM-Tg-equg-T30035-Ab-1/ GM-Tg-equg-T30035-Ab-2 | Anti-Equine STC1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T30035-Ab-1/ GM-Tg-hg-T30035-Ab-2; GM-Tg-rg-T30035-Ab-1/ GM-Tg-rg-T30035-Ab-2; GM-Tg-mg-T30035-Ab-1/ GM-Tg-mg-T30035-Ab-2; GM-Tg-cynog-T30035-Ab-1/ GM-Tg-cynog-T30035-Ab-2; GM-Tg-felg-T30035-Ab-1/ GM-Tg-felg-T30035-Ab-2; GM-Tg-cang-T30035-Ab-1/ GM-Tg-cang-T30035-Ab-2; GM-Tg-bovg-T30035-Ab-1/ GM-Tg-bovg-T30035-Ab-2; GM-Tg-equg-T30035-Ab-1/ GM-Tg-equg-T30035-Ab-2 |
| Products Name | Anti-STC1 monoclonal antibody |
| Format | mab |
| Target Name | STC1 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-STC1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T30035-Ag-1 | Recombinant multi-species STC1/ STC protein |
| ORF Viral Vector | vGMLP002331 | human STC1 Lentivirus particle |
| ORF Viral Vector | pGMLP002331 | human STC1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002440 | mouse Stc1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002440 | mouse Stc1 Lentivirus particle |
Target information
| Target ID | GM-T30035 |
| Target Name | STC1 |
| Gene ID | 6781,20855,81801,710782,486112,101083584,338078,100054071 |
| Gene Symbol and Synonyms | STC,STC1 |
| Uniprot Accession | P52823,P97574,Q9N0T1 |
| Uniprot Entry Name | STC1_HUMAN,STC1_RAT,STC1_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000159167 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: STC1, gene name: STC1, also named as STC. This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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