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Anti-POSTN/ OSF-2/ OSF2 functional antibody
Anti-POSTN/ OSF-2/ OSF2 functional antibody for cell culture, ELISA & in-vivo assay
Go to POSTN/POSTN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T29187-Ab-1/ GM-Tg-hg-T29187-Ab-2 | Anti-Human POSTN monoclonal antibody | Human |
| GM-Tg-rg-T29187-Ab-1/ GM-Tg-rg-T29187-Ab-2 | Anti-Rat POSTN monoclonal antibody | Rat |
| GM-Tg-mg-T29187-Ab-1/ GM-Tg-mg-T29187-Ab-2 | Anti-Mouse POSTN monoclonal antibody | Mouse |
| GM-Tg-cynog-T29187-Ab-1/ GM-Tg-cynog-T29187-Ab-2 | Anti-Cynomolgus/ Rhesus macaque POSTN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T29187-Ab-1/ GM-Tg-felg-T29187-Ab-2 | Anti-Feline POSTN monoclonal antibody | Feline |
| GM-Tg-cang-T29187-Ab-1/ GM-Tg-cang-T29187-Ab-2 | Anti-Canine POSTN monoclonal antibody | Canine |
| GM-Tg-bovg-T29187-Ab-1/ GM-Tg-bovg-T29187-Ab-2 | Anti-Bovine POSTN monoclonal antibody | Bovine |
| GM-Tg-equg-T29187-Ab-1/ GM-Tg-equg-T29187-Ab-2 | Anti-Equine POSTN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T29187-Ab-1/ GM-Tg-hg-T29187-Ab-2; GM-Tg-rg-T29187-Ab-1/ GM-Tg-rg-T29187-Ab-2; GM-Tg-mg-T29187-Ab-1/ GM-Tg-mg-T29187-Ab-2; GM-Tg-cynog-T29187-Ab-1/ GM-Tg-cynog-T29187-Ab-2; GM-Tg-felg-T29187-Ab-1/ GM-Tg-felg-T29187-Ab-2; GM-Tg-cang-T29187-Ab-1/ GM-Tg-cang-T29187-Ab-2; GM-Tg-bovg-T29187-Ab-1/ GM-Tg-bovg-T29187-Ab-2; GM-Tg-equg-T29187-Ab-1/ GM-Tg-equg-T29187-Ab-2 |
| Products Name | Anti-POSTN monoclonal antibody |
| Format | mab |
| Target Name | POSTN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-POSTN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T29187-Ag-1 | Recombinant multi-species POSTN/ OSF-2/ OSF2 protein |
| ORF Viral Vector | vGMLV000342 | human POSTN Lentivirus particle |
| ORF Viral Vector | pGMLV000342 | human POSTN Lentivirus plasmid |
| ORF Viral Vector | pGMAD000273 | mouse Postn Adenovirus plasmid |
| ORF Viral Vector | pGMAAV000318 | house mouse Postn AAV plasmid |
| ORF Viral Vector | vGMAD000273 | mouse Postn Adenovirus particle |
| ORF Viral Vector | vGMAAV000318 | house mouse Postn AAV particle |
Target information
| Target ID | GM-T29187 |
| Target Name | POSTN |
| Gene ID | 10631,50706,361945,695528,477298,101088807,281960,100062608 |
| Gene Symbol and Synonyms | A630052E07Rik,OSF-2,OSF2,PDLPOSTN,PLF,PN,POSTN |
| Uniprot Accession | Q15063 |
| Uniprot Entry Name | POSTN_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Ovary Cancer, Complications of kidney transplant, Diabetic Nephropathy |
| Gene Ensembl | ENSG00000133110 |
| Target Classification | N/A |
The target: POSTN, gene name: POSTN, also named as OSF-2, OSF2, PDLPOSTN, PN. This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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