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Anti-HDAC8/ CDA07/ CDLS5 monoclonal antibody
Anti-HDAC8/ CDA07/ CDLS5 antibody for FACS & in-vivo assay
Go to HDAC8/HDAC8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T28887-Ab-1/ GM-Tg-hg-T28887-Ab-2 | Anti-Human HDAC8 monoclonal antibody | Human |
| GM-Tg-rg-T28887-Ab-1/ GM-Tg-rg-T28887-Ab-2 | Anti-Rat HDAC8 monoclonal antibody | Rat |
| GM-Tg-mg-T28887-Ab-1/ GM-Tg-mg-T28887-Ab-2 | Anti-Mouse HDAC8 monoclonal antibody | Mouse |
| GM-Tg-cynog-T28887-Ab-1/ GM-Tg-cynog-T28887-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HDAC8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T28887-Ab-1/ GM-Tg-felg-T28887-Ab-2 | Anti-Feline HDAC8 monoclonal antibody | Feline |
| GM-Tg-cang-T28887-Ab-1/ GM-Tg-cang-T28887-Ab-2 | Anti-Canine HDAC8 monoclonal antibody | Canine |
| GM-Tg-bovg-T28887-Ab-1/ GM-Tg-bovg-T28887-Ab-2 | Anti-Bovine HDAC8 monoclonal antibody | Bovine |
| GM-Tg-equg-T28887-Ab-1/ GM-Tg-equg-T28887-Ab-2 | Anti-Equine HDAC8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T28887-Ab-1/ GM-Tg-hg-T28887-Ab-2; GM-Tg-rg-T28887-Ab-1/ GM-Tg-rg-T28887-Ab-2; GM-Tg-mg-T28887-Ab-1/ GM-Tg-mg-T28887-Ab-2; GM-Tg-cynog-T28887-Ab-1/ GM-Tg-cynog-T28887-Ab-2; GM-Tg-felg-T28887-Ab-1/ GM-Tg-felg-T28887-Ab-2; GM-Tg-cang-T28887-Ab-1/ GM-Tg-cang-T28887-Ab-2; GM-Tg-bovg-T28887-Ab-1/ GM-Tg-bovg-T28887-Ab-2; GM-Tg-equg-T28887-Ab-1/ GM-Tg-equg-T28887-Ab-2 |
| Products Name | Anti-HDAC8 monoclonal antibody |
| Format | mab |
| Target Name | HDAC8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HDAC8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species HDAC8/ CDA07/ CDLS5 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001200 | human HDAC8 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001200 | human HDAC8 Lentivirus particle |
| ORF Viral Vector | pGMLPm002931 | mouse Hdac8 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002931 | mouse Hdac8 Lentivirus particle |
Target information
| Target ID | GM-T28887 |
| Target Name | HDAC8 |
| Gene ID | 55869,70315,363481,699642,480957,101096383,540666,100052401 |
| Gene Symbol and Synonyms | 2610007D20Rik,CDA07,CDLS5,HD8,HDAC8,HDACL1,KDAC8,MRXS6,RGD1562895,RPD3,WTS |
| Uniprot Accession | Q9BY41,B1WC68,Q0VCB2 |
| Uniprot Entry Name | HDAC8_HUMAN,HDAC8_RAT,HDAC8_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000147099 |
| Target Classification | N/A |
The target: HDAC8, gene name: HDAC8, also named as CDA07, CDLS5, HD8, HDACL1, MRXS6, RPD3, WTS. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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