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Anti-TNR12/ TNFRSF12A/ CD266 monoclonal antibody
Anti-TNR12/ TNFRSF12A/ CD266 antibody for FACS & in-vivo assay
Go to TNFRSF12A/TNFRSF12A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T28717-Ab-1/ GM-Tg-hg-T28717-Ab-2 | Anti-Human TNFRSF12A monoclonal antibody | Human |
| GM-Tg-rg-T28717-Ab-1/ GM-Tg-rg-T28717-Ab-2 | Anti-Rat TNFRSF12A monoclonal antibody | Rat |
| GM-Tg-mg-T28717-Ab-1/ GM-Tg-mg-T28717-Ab-2 | Anti-Mouse TNFRSF12A monoclonal antibody | Mouse |
| GM-Tg-cynog-T28717-Ab-1/ GM-Tg-cynog-T28717-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNFRSF12A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T28717-Ab-1/ GM-Tg-felg-T28717-Ab-2 | Anti-Feline TNFRSF12A monoclonal antibody | Feline |
| GM-Tg-cang-T28717-Ab-1/ GM-Tg-cang-T28717-Ab-2 | Anti-Canine TNFRSF12A monoclonal antibody | Canine |
| GM-Tg-bovg-T28717-Ab-1/ GM-Tg-bovg-T28717-Ab-2 | Anti-Bovine TNFRSF12A monoclonal antibody | Bovine |
| GM-Tg-equg-T28717-Ab-1/ GM-Tg-equg-T28717-Ab-2 | Anti-Equine TNFRSF12A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T28717-Ab-1/ GM-Tg-hg-T28717-Ab-2; GM-Tg-rg-T28717-Ab-1/ GM-Tg-rg-T28717-Ab-2; GM-Tg-mg-T28717-Ab-1/ GM-Tg-mg-T28717-Ab-2; GM-Tg-cynog-T28717-Ab-1/ GM-Tg-cynog-T28717-Ab-2; GM-Tg-felg-T28717-Ab-1/ GM-Tg-felg-T28717-Ab-2; GM-Tg-cang-T28717-Ab-1/ GM-Tg-cang-T28717-Ab-2; GM-Tg-bovg-T28717-Ab-1/ GM-Tg-bovg-T28717-Ab-2; GM-Tg-equg-T28717-Ab-1/ GM-Tg-equg-T28717-Ab-2 |
| Products Name | Anti-TNFRSF12A monoclonal antibody |
| Format | mab |
| Target Name | TNFRSF12A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNFRSF12A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-180 | Pre-Made Enavatuzumab biosimilar, Whole mAb, Anti-TNFRSF12A Antibody: Anti-CD2664/TWEAKR therapeutic antibody |
| Target Antigen | Products Developing | Multi-species TNR12/ TNFRSF12A/ CD266 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T28717-Ag-1 | Tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A) protein |
| ORF Viral Vector | pGMLP000633 | human TNFRSF12A Lentivirus plasmid |
| ORF Viral Vector | vGMLP000633 | human TNFRSF12A Lentivirus particle |
| ORF Viral Vector | pGMLPm000219 | mouse Tnfrsf12a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000219 | mouse Tnfrsf12a Lentivirus particle |
Target information
| Target ID | GM-T28717 |
| Target Name | TNFRSF12A |
| Gene ID | 51330,27279,302965,699970,610734,101098186,617439,100146755 |
| Gene Symbol and Synonyms | CD266,FN14,HPIP,TNFRSF12A,TWEAK-R,TWEAKR |
| Uniprot Accession | Q9NP84 |
| Uniprot Entry Name | TNR12_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000006327 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TNFRSF12A, gene name: TNFRSF12A, also named as CD266, FN14, TWEAKR. Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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