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Anti-CCKAR/ CCK-A/ CCK1-R monoclonal antibody
Anti-CCKAR/ CCK-A/ CCK1-R antibody for FACS & in-vivo assay
Go to CCKAR/CCKAR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T28330-Ab-1/ GM-Tg-hg-T28330-Ab-2 | Anti-Human CCKAR monoclonal antibody | Human |
| GM-Tg-rg-T28330-Ab-1/ GM-Tg-rg-T28330-Ab-2 | Anti-Rat CCKAR monoclonal antibody | Rat |
| GM-Tg-mg-T28330-Ab-1/ GM-Tg-mg-T28330-Ab-2 | Anti-Mouse CCKAR monoclonal antibody | Mouse |
| GM-Tg-cynog-T28330-Ab-1/ GM-Tg-cynog-T28330-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CCKAR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T28330-Ab-1/ GM-Tg-felg-T28330-Ab-2 | Anti-Feline CCKAR monoclonal antibody | Feline |
| GM-Tg-cang-T28330-Ab-1/ GM-Tg-cang-T28330-Ab-2 | Anti-Canine CCKAR monoclonal antibody | Canine |
| GM-Tg-bovg-T28330-Ab-1/ GM-Tg-bovg-T28330-Ab-2 | Anti-Bovine CCKAR monoclonal antibody | Bovine |
| GM-Tg-equg-T28330-Ab-1/ GM-Tg-equg-T28330-Ab-2 | Anti-Equine CCKAR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T28330-Ab-1/ GM-Tg-hg-T28330-Ab-2; GM-Tg-rg-T28330-Ab-1/ GM-Tg-rg-T28330-Ab-2; GM-Tg-mg-T28330-Ab-1/ GM-Tg-mg-T28330-Ab-2; GM-Tg-cynog-T28330-Ab-1/ GM-Tg-cynog-T28330-Ab-2; GM-Tg-felg-T28330-Ab-1/ GM-Tg-felg-T28330-Ab-2; GM-Tg-cang-T28330-Ab-1/ GM-Tg-cang-T28330-Ab-2; GM-Tg-bovg-T28330-Ab-1/ GM-Tg-bovg-T28330-Ab-2; GM-Tg-equg-T28330-Ab-1/ GM-Tg-equg-T28330-Ab-2 |
| Products Name | Anti-CCKAR monoclonal antibody |
| Format | mab |
| Target Name | CCKAR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CCKAR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species CCKAR/ CCK-A/ CCK1-R VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP002992 | human CCKAR Lentivirus particle |
| ORF Viral Vector | pGMLP002992 | human CCKAR Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001768 | mouse Cckar Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001768 | mouse Cckar Lentivirus particle |
Target information
| Target ID | GM-T28330 |
| Target Name | CCKAR |
| Gene ID | 886,12425,24889,694742,488846,101099960,506207,100055506 |
| Gene Symbol and Synonyms | CCK-A,Cck-ar,CCK1-R,CCK1R,CCKAR,CCKRA |
| Uniprot Accession | P32238,P30551,Q5D0K2 |
| Uniprot Entry Name | CCKAR_HUMAN,CCKAR_RAT,CCKAR_CANLF |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000163394 |
| Target Classification | GPCR |
The target: CCKAR, gene name: CCKAR, also named as CCK-A, CCK1-R, CCK1R, CCKRA. This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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