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Anti-FGF4/ FGF-4/ HBGF-4 functional antibody
Anti-FGF4/ FGF-4/ HBGF-4 functional antibody for cell culture, ELISA & in-vivo assay
Go to FGF4/FGF4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T28076-Ab-1/ GM-Tg-hg-T28076-Ab-2 | Anti-Human FGF4 monoclonal antibody | Human |
| GM-Tg-rg-T28076-Ab-1/ GM-Tg-rg-T28076-Ab-2 | Anti-Rat FGF4 monoclonal antibody | Rat |
| GM-Tg-mg-T28076-Ab-1/ GM-Tg-mg-T28076-Ab-2 | Anti-Mouse FGF4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T28076-Ab-1/ GM-Tg-cynog-T28076-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FGF4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T28076-Ab-1/ GM-Tg-felg-T28076-Ab-2 | Anti-Feline FGF4 monoclonal antibody | Feline |
| GM-Tg-cang-T28076-Ab-1/ GM-Tg-cang-T28076-Ab-2 | Anti-Canine FGF4 monoclonal antibody | Canine |
| GM-Tg-bovg-T28076-Ab-1/ GM-Tg-bovg-T28076-Ab-2 | Anti-Bovine FGF4 monoclonal antibody | Bovine |
| GM-Tg-equg-T28076-Ab-1/ GM-Tg-equg-T28076-Ab-2 | Anti-Equine FGF4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T28076-Ab-1/ GM-Tg-hg-T28076-Ab-2; GM-Tg-rg-T28076-Ab-1/ GM-Tg-rg-T28076-Ab-2; GM-Tg-mg-T28076-Ab-1/ GM-Tg-mg-T28076-Ab-2; GM-Tg-cynog-T28076-Ab-1/ GM-Tg-cynog-T28076-Ab-2; GM-Tg-felg-T28076-Ab-1/ GM-Tg-felg-T28076-Ab-2; GM-Tg-cang-T28076-Ab-1/ GM-Tg-cang-T28076-Ab-2; GM-Tg-bovg-T28076-Ab-1/ GM-Tg-bovg-T28076-Ab-2; GM-Tg-equg-T28076-Ab-1/ GM-Tg-equg-T28076-Ab-2 |
| Products Name | Anti-FGF4 monoclonal antibody |
| Format | mab |
| Target Name | FGF4 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-FGF4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T28076-Ag-1 | Recombinant multi-species FGF4/ FGF-4/ HBGF-4 protein |
| Cytokine | GM-Tg-g-T28076-Ag-1 | fibroblast growth factor 4 (FGF4) protein |
| ORF Viral Vector | pGMLP003446 | human FGF4 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003446 | human FGF4 Lentivirus particle |
| ORF Viral Vector | pGMLPm004481 | mouse Fgf4 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004481 | mouse Fgf4 Lentivirus particle |
Target information
| Target ID | GM-T28076 |
| Target Name | FGF4 |
| Gene ID | 2249,14175,116499,709016,483680,111556546,618474,100060525 |
| Gene Symbol and Synonyms | FGF-4,FGF4,Fgf7a,Fgfk,HBGF-4,HST,HST-1,Hst1,HSTF-1,HSTF1,K-FGF,KFGF,KS3 |
| Uniprot Accession | P08620,P48803 |
| Uniprot Entry Name | FGF4_HUMAN,FGF4_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000075388 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: FGF4, gene name: FGF4, also named as FGF-4, HBGF-4, HST, HST-1, HSTF-1, HSTF1, K-FGF, KFGF. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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