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Anti-ACE2/ ACEH monoclonal antibody
Anti-ACE2/ ACEH antibody for FACS & in-vivo assay
Go to ACE2/ACE2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T27889-Ab-1/ GM-Tg-hg-T27889-Ab-2 | Anti-Human ACE2 monoclonal antibody | Human |
| GM-Tg-rg-T27889-Ab-1/ GM-Tg-rg-T27889-Ab-2 | Anti-Rat ACE2 monoclonal antibody | Rat |
| GM-Tg-mg-T27889-Ab-1/ GM-Tg-mg-T27889-Ab-2 | Anti-Mouse ACE2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T27889-Ab-1/ GM-Tg-cynog-T27889-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ACE2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T27889-Ab-1/ GM-Tg-felg-T27889-Ab-2 | Anti-Feline ACE2 monoclonal antibody | Feline |
| GM-Tg-cang-T27889-Ab-1/ GM-Tg-cang-T27889-Ab-2 | Anti-Canine ACE2 monoclonal antibody | Canine |
| GM-Tg-bovg-T27889-Ab-1/ GM-Tg-bovg-T27889-Ab-2 | Anti-Bovine ACE2 monoclonal antibody | Bovine |
| GM-Tg-equg-T27889-Ab-1/ GM-Tg-equg-T27889-Ab-2 | Anti-Equine ACE2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T27889-Ab-1/ GM-Tg-hg-T27889-Ab-2; GM-Tg-rg-T27889-Ab-1/ GM-Tg-rg-T27889-Ab-2; GM-Tg-mg-T27889-Ab-1/ GM-Tg-mg-T27889-Ab-2; GM-Tg-cynog-T27889-Ab-1/ GM-Tg-cynog-T27889-Ab-2; GM-Tg-felg-T27889-Ab-1/ GM-Tg-felg-T27889-Ab-2; GM-Tg-cang-T27889-Ab-1/ GM-Tg-cang-T27889-Ab-2; GM-Tg-bovg-T27889-Ab-1/ GM-Tg-bovg-T27889-Ab-2; GM-Tg-equg-T27889-Ab-1/ GM-Tg-equg-T27889-Ab-2 |
| Products Name | Anti-ACE2 monoclonal antibody |
| Format | mab |
| Target Name | ACE2 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ACE2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species ACE2/ ACEH VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm000599 | mouse Ace2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000599 | mouse Ace2 Lentivirus particle |
Target information
| Target ID | GM-T27889 |
| Target Name | ACE2 |
| Gene ID | 59272,70008,302668,712790,480847,554349,509235,100055952 |
| Gene Symbol and Synonyms | 2010305L05Rik,ACE-2,ACE2,ACEH |
| Uniprot Accession | Q9BYF1,Q5EGZ1,Q56H28,Q58DD0 |
| Uniprot Entry Name | ACE2_HUMAN,ACE2_RAT,ACE2_FELCA,ACE2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | Type 2 diabetes mellitus |
| Gene Ensembl | ENSG00000130234 |
| Target Classification | N/A |
The target: ACE2, gene name: ACE2, also named as ACEH. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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