Anti-ACE2/ ACEH monoclonal antibody

Anti-ACE2/ ACEH antibody for FACS & in-vivo assay

Target products collectionGo to ACE2/ACE2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T27889-Ab-1/ GM-Tg-hg-T27889-Ab-2Anti-Human ACE2 monoclonal antibodyHuman
GM-Tg-rg-T27889-Ab-1/ GM-Tg-rg-T27889-Ab-2Anti-Rat ACE2 monoclonal antibodyRat
GM-Tg-mg-T27889-Ab-1/ GM-Tg-mg-T27889-Ab-2Anti-Mouse ACE2 monoclonal antibodyMouse
GM-Tg-cynog-T27889-Ab-1/ GM-Tg-cynog-T27889-Ab-2Anti-Cynomolgus/ Rhesus macaque ACE2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T27889-Ab-1/ GM-Tg-felg-T27889-Ab-2Anti-Feline ACE2 monoclonal antibodyFeline
GM-Tg-cang-T27889-Ab-1/ GM-Tg-cang-T27889-Ab-2Anti-Canine ACE2 monoclonal antibodyCanine
GM-Tg-bovg-T27889-Ab-1/ GM-Tg-bovg-T27889-Ab-2Anti-Bovine ACE2 monoclonal antibodyBovine
GM-Tg-equg-T27889-Ab-1/ GM-Tg-equg-T27889-Ab-2Anti-Equine ACE2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T27889-Ab-1/ GM-Tg-hg-T27889-Ab-2; GM-Tg-rg-T27889-Ab-1/ GM-Tg-rg-T27889-Ab-2;
GM-Tg-mg-T27889-Ab-1/ GM-Tg-mg-T27889-Ab-2; GM-Tg-cynog-T27889-Ab-1/ GM-Tg-cynog-T27889-Ab-2;
GM-Tg-felg-T27889-Ab-1/ GM-Tg-felg-T27889-Ab-2; GM-Tg-cang-T27889-Ab-1/ GM-Tg-cang-T27889-Ab-2;
GM-Tg-bovg-T27889-Ab-1/ GM-Tg-bovg-T27889-Ab-2; GM-Tg-equg-T27889-Ab-1/ GM-Tg-equg-T27889-Ab-2
Products NameAnti-ACE2 monoclonal antibody
Formatmab
Target NameACE2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ACE2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species ACE2/ ACEH VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm000599mouse Ace2 Lentivirus plasmid
    ORF Viral VectorvGMLPm000599mouse Ace2 Lentivirus particle


    Target information

    Target IDGM-T27889
    Target NameACE2
    Gene ID59272,70008,302668,712790,480847,554349,509235,100055952
    Gene Symbol and Synonyms2010305L05Rik,ACE-2,ACE2,ACEH
    Uniprot AccessionQ9BYF1,Q5EGZ1,Q56H28,Q58DD0
    Uniprot Entry NameACE2_HUMAN,ACE2_RAT,ACE2_FELCA,ACE2_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Diagnostics Biomarker
    DiseaseType 2 diabetes mellitus
    Gene EnsemblENSG00000130234
    Target ClassificationN/A

    The target: ACE2, gene name: ACE2, also named as ACEH. The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. ACE2 is known to be expressed in various human organs, and its organ- and cell-specific expression suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronavirus HCoV-NL63 and the human severe acute respiratory syndrome coronaviruses, SARS-CoV and SARS-CoV-2, the latter is the causative agent of coronavirus disease-2019 (COVID-19). Multiple splice variants have been found for this gene and the dACE2 (or MIRb-ACE2) splice variant has been found to be interferon inducible. [provided by RefSeq, Nov 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.