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Anti-S10A8/ S100A8/ 60B8AG monoclonal antibody
Anti-S10A8/ S100A8/ 60B8AG antibody for FACS & in-vivo assay
Go to S100A8/S100A8 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T27402-Ab-1/ GM-Tg-hg-T27402-Ab-2 | Anti-Human S100A8 monoclonal antibody | Human |
| GM-Tg-rg-T27402-Ab-1/ GM-Tg-rg-T27402-Ab-2 | Anti-Rat S100A8 monoclonal antibody | Rat |
| GM-Tg-mg-T27402-Ab-1/ GM-Tg-mg-T27402-Ab-2 | Anti-Mouse S100A8 monoclonal antibody | Mouse |
| GM-Tg-cynog-T27402-Ab-1/ GM-Tg-cynog-T27402-Ab-2 | Anti-Cynomolgus/ Rhesus macaque S100A8 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T27402-Ab-1/ GM-Tg-felg-T27402-Ab-2 | Anti-Feline S100A8 monoclonal antibody | Feline |
| GM-Tg-cang-T27402-Ab-1/ GM-Tg-cang-T27402-Ab-2 | Anti-Canine S100A8 monoclonal antibody | Canine |
| GM-Tg-bovg-T27402-Ab-1/ GM-Tg-bovg-T27402-Ab-2 | Anti-Bovine S100A8 monoclonal antibody | Bovine |
| GM-Tg-equg-T27402-Ab-1/ GM-Tg-equg-T27402-Ab-2 | Anti-Equine S100A8 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T27402-Ab-1/ GM-Tg-hg-T27402-Ab-2; GM-Tg-rg-T27402-Ab-1/ GM-Tg-rg-T27402-Ab-2; GM-Tg-mg-T27402-Ab-1/ GM-Tg-mg-T27402-Ab-2; GM-Tg-cynog-T27402-Ab-1/ GM-Tg-cynog-T27402-Ab-2; GM-Tg-felg-T27402-Ab-1/ GM-Tg-felg-T27402-Ab-2; GM-Tg-cang-T27402-Ab-1/ GM-Tg-cang-T27402-Ab-2; GM-Tg-bovg-T27402-Ab-1/ GM-Tg-bovg-T27402-Ab-2; GM-Tg-equg-T27402-Ab-1/ GM-Tg-equg-T27402-Ab-2 |
| Products Name | Anti-S100A8 monoclonal antibody |
| Format | mab |
| Target Name | S100A8 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-S100A8 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species S10A8/ S100A8/ 60B8AG VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLV000751 | human S100A8 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000491 | human S100A8 Lentivirus plasmid |
| ORF Viral Vector | vGMLP000464 | human S100A8 Lentivirus particle |
| ORF Viral Vector | vGMLV000491 | human S100A8 Lentivirus particle |
| ORF Viral Vector | vGMLV000751 | human S100A8 Lentivirus particle |
| ORF Viral Vector | vGMAP000312 | Human S100A8 Adenovirus particle |
| ORF Viral Vector | pGMAP000312 | Human S100A8 Adenovirus plasmid |
| ORF Viral Vector | pGMLP000464 | human S100A8 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000279 | mouse S100a8 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000279 | mouse S100a8 Lentivirus particle |
Target information
| Target ID | GM-T27402 |
| Target Name | S100A8 |
| Gene ID | 6279,20201,116547,714740,490461,101084164,616818,100061766 |
| Gene Symbol and Synonyms | 60B8AG,B8Ag,CAGA,CFAG,CGLA,CP-10,L1Ag,MA387,MIF,MRP8,NIF,P8,S100-A8,S100A8 |
| Uniprot Accession | P05109,P50115,P28782 |
| Uniprot Entry Name | S10A8_HUMAN,S10A8_RAT,S10A8_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | Acute appendicitis, Congenital occlusion of ureteropelvic junction, Contact with and (suspected) exposure to environmental tobacco smoke (acute) (chronic), Malignant neoplasm of bladder |
| Gene Ensembl | ENSG00000143546 |
| Target Classification | N/A |
The target: S100A8, gene name: S100A8, also named as 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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