Anti-GPC3/ DGSX/ GTR2-2 monoclonal antibody

Anti-GPC3/ DGSX/ GTR2-2 antibody for FACS & in-vivo assay

Target products collectionGo to GPC3/GPC3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T25726-Ab-1/ GM-Tg-hg-T25726-Ab-2Anti-Human GPC3 monoclonal antibodyHuman
GM-Tg-rg-T25726-Ab-1/ GM-Tg-rg-T25726-Ab-2Anti-Rat GPC3 monoclonal antibodyRat
GM-Tg-mg-T25726-Ab-1/ GM-Tg-mg-T25726-Ab-2Anti-Mouse GPC3 monoclonal antibodyMouse
GM-Tg-cynog-T25726-Ab-1/ GM-Tg-cynog-T25726-Ab-2Anti-Cynomolgus/ Rhesus macaque GPC3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T25726-Ab-1/ GM-Tg-felg-T25726-Ab-2Anti-Feline GPC3 monoclonal antibodyFeline
GM-Tg-cang-T25726-Ab-1/ GM-Tg-cang-T25726-Ab-2Anti-Canine GPC3 monoclonal antibodyCanine
GM-Tg-bovg-T25726-Ab-1/ GM-Tg-bovg-T25726-Ab-2Anti-Bovine GPC3 monoclonal antibodyBovine
GM-Tg-equg-T25726-Ab-1/ GM-Tg-equg-T25726-Ab-2Anti-Equine GPC3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T25726-Ab-1/ GM-Tg-hg-T25726-Ab-2; GM-Tg-rg-T25726-Ab-1/ GM-Tg-rg-T25726-Ab-2;
GM-Tg-mg-T25726-Ab-1/ GM-Tg-mg-T25726-Ab-2; GM-Tg-cynog-T25726-Ab-1/ GM-Tg-cynog-T25726-Ab-2;
GM-Tg-felg-T25726-Ab-1/ GM-Tg-felg-T25726-Ab-2; GM-Tg-cang-T25726-Ab-1/ GM-Tg-cang-T25726-Ab-2;
GM-Tg-bovg-T25726-Ab-1/ GM-Tg-bovg-T25726-Ab-2; GM-Tg-equg-T25726-Ab-1/ GM-Tg-equg-T25726-Ab-2
Products NameAnti-GPC3 monoclonal antibody
Formatmab
Target NameGPC3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-GPC3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-114Pre-Made Codrituzumab biosimilar, Whole mAb, Anti-GPC3 Antibody: Anti-DGSX/GTR2-2/MXR7/OCI-5/SDYS/SGB/SGBS/SGBS1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species GPC3/ DGSX/ GTR2-2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLPm001108mouse Gpc3 Lentivirus plasmid
    ORF Viral VectorvGMLPm001108mouse Gpc3 Lentivirus particle


    Target information

    Target IDGM-T25726
    Target NameGPC3
    Gene ID2719,14734,25236,706773,481056,101094739,615239,100054222
    Gene Symbol and SynonymsDGSX,GPC3,GTR2-2,MXR7,OCI-5,SDYS,SGB,SGBS,SGBS1
    Uniprot AccessionP51654,P13265
    Uniprot Entry NameGPC3_HUMAN,GPC3_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseCancer
    Gene EnsemblENSG00000147257
    Target ClassificationCheckpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The target: GPC3, gene name: GPC3, also named as DGSX, GTR2-2, MXR7, OCI-5, SDYS, SGB, SGBS, SGBS1. Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.