Anti-CXCR3/ CD182/ CD183 monoclonal antibody

Anti-CXCR3/ CD182/ CD183 antibody for FACS & in-vivo assay

Target products collectionGo to CXCR3/CXCR3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T25315-Ab-1/ GM-Tg-hg-T25315-Ab-2Anti-Human CXCR3 monoclonal antibodyHuman
GM-Tg-rg-T25315-Ab-1/ GM-Tg-rg-T25315-Ab-2Anti-Rat CXCR3 monoclonal antibodyRat
GM-Tg-mg-T25315-Ab-1/ GM-Tg-mg-T25315-Ab-2Anti-Mouse CXCR3 monoclonal antibodyMouse
GM-Tg-cynog-T25315-Ab-1/ GM-Tg-cynog-T25315-Ab-2Anti-Cynomolgus/ Rhesus macaque CXCR3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T25315-Ab-1/ GM-Tg-felg-T25315-Ab-2Anti-Feline CXCR3 monoclonal antibodyFeline
GM-Tg-cang-T25315-Ab-1/ GM-Tg-cang-T25315-Ab-2Anti-Canine CXCR3 monoclonal antibodyCanine
GM-Tg-bovg-T25315-Ab-1/ GM-Tg-bovg-T25315-Ab-2Anti-Bovine CXCR3 monoclonal antibodyBovine
GM-Tg-equg-T25315-Ab-1/ GM-Tg-equg-T25315-Ab-2Anti-Equine CXCR3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T25315-Ab-1/ GM-Tg-hg-T25315-Ab-2; GM-Tg-rg-T25315-Ab-1/ GM-Tg-rg-T25315-Ab-2;
GM-Tg-mg-T25315-Ab-1/ GM-Tg-mg-T25315-Ab-2; GM-Tg-cynog-T25315-Ab-1/ GM-Tg-cynog-T25315-Ab-2;
GM-Tg-felg-T25315-Ab-1/ GM-Tg-felg-T25315-Ab-2; GM-Tg-cang-T25315-Ab-1/ GM-Tg-cang-T25315-Ab-2;
GM-Tg-bovg-T25315-Ab-1/ GM-Tg-bovg-T25315-Ab-2; GM-Tg-equg-T25315-Ab-1/ GM-Tg-equg-T25315-Ab-2
Products NameAnti-CXCR3 monoclonal antibody
Formatmab
Target NameCXCR3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CXCR3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CXCR3/ CD182/ CD183 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T25315-Ag-1chemokine (C-X-C motif) receptor 3 (CXCR3) protein
    ORF Viral VectorvGMAP000322Human CXCR3 Adenovirus particle
    ORF Viral VectorpGMAP000322Human CXCR3 Adenovirus plasmid
    ORF Viral VectorpGMLPm002785mouse Cxcr3 Lentivirus plasmid
    ORF Viral VectorvGMLPm002785mouse Cxcr3 Lentivirus particle


    Target information

    Target IDGM-T25315
    Target NameCXCR3
    Gene ID2833,12766,84475,699438,491952,101094573,497018,100056190
    Gene Symbol and SynonymsCD182,CD183,CKR-L2,CMKAR3,CXCR3,GPR9,IP10-R,Mig-R,MigR
    Uniprot AccessionP49682,Q9JII9,Q5KSK8,Q5MD61
    Uniprot Entry NameCXCR3_HUMAN,CXCR3_RAT,CXCR3_CANLF,CXCR3_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000186810
    Target ClassificationCheckpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA)

    The target: CXCR3, gene name: CXCR3, also named as CD182, CD183, CKR-L2, CMKAR3, GPR9, IP10-R, Mig-R, MigR. This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716). [provided by RefSeq, Jun 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.