Anti-EZH2 monoclonal antibody

Pre-made anti-EZH2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to EZH2/EZH2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T25265-Ab-1/ GM-Tg-hg-T25265-Ab-2Anti-Human EZH2 monoclonal antibodyHuman
GM-Tg-rg-T25265-Ab-1/ GM-Tg-rg-T25265-Ab-2Anti-Rat EZH2 monoclonal antibodyRat
GM-Tg-mg-T25265-Ab-1/ GM-Tg-mg-T25265-Ab-2Anti-Mouse EZH2 monoclonal antibodyMouse
GM-Tg-cynog-T25265-Ab-1/ GM-Tg-cynog-T25265-Ab-2Anti-Cynomolgus/ Rhesus macaque EZH2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T25265-Ab-1/ GM-Tg-felg-T25265-Ab-2Anti-Feline EZH2 monoclonal antibodyFeline
GM-Tg-cang-T25265-Ab-1/ GM-Tg-cang-T25265-Ab-2Anti-Canine EZH2 monoclonal antibodyCanine
GM-Tg-bovg-T25265-Ab-1/ GM-Tg-bovg-T25265-Ab-2Anti-Bovine EZH2 monoclonal antibodyBovine
GM-Tg-equg-T25265-Ab-1/ GM-Tg-equg-T25265-Ab-2Anti-Equine EZH2 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T25265-Ab-1/ GM-Tg-hg-T25265-Ab-2; GM-Tg-rg-T25265-Ab-1/ GM-Tg-rg-T25265-Ab-2;
GM-Tg-mg-T25265-Ab-1/ GM-Tg-mg-T25265-Ab-2; GM-Tg-cynog-T25265-Ab-1/ GM-Tg-cynog-T25265-Ab-2;
GM-Tg-felg-T25265-Ab-1/ GM-Tg-felg-T25265-Ab-2; GM-Tg-cang-T25265-Ab-1/ GM-Tg-cang-T25265-Ab-2;
GM-Tg-bovg-T25265-Ab-1/ GM-Tg-bovg-T25265-Ab-2; GM-Tg-equg-T25265-Ab-1/ GM-Tg-equg-T25265-Ab-2
Products NameAnti-EZH2 monoclonal antibody
Formatmab
Target NameEZH2
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-EZH2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T25265-Ag-1Recombinant multi-species EZH2/ ENX-1/ ENX1b protein
    ORF Viral VectorvGMLV000239human EZH2 Lentivirus particle
    ORF Viral VectorpGMLV000587human EZH2 Lentivirus plasmid
    ORF Viral VectorvGMLV000587human EZH2 Lentivirus particle
    ORF Viral VectorpGMLV000239human EZH2 Lentivirus plasmid
    ORF Viral VectorpGMAD000205mouse Ezh2 Adenovirus plasmid
    ORF Viral VectorpGMAD000643house mouse Ezh2 Adenovirus plasmid
    ORF Viral VectorpGMAD000644house mouse Ezh2 Adenovirus plasmid
    ORF Viral VectorpGMAAV000342house mouse Ezh2 AAV plasmid
    ORF Viral VectorpGMAAV000343house mouse Ezh2 AAV plasmid
    ORF Viral VectorvGMAD000205mouse Ezh2 Adenovirus particle
    ORF Viral VectorvGMAD000643house mouse Ezh2 Adenovirus particle
    ORF Viral VectorvGMAD000644house mouse Ezh2 Adenovirus particle
    ORF Viral VectorvGMAAV000342house mouse Ezh2 AAV particle
    ORF Viral VectorvGMAAV000343house mouse Ezh2 AAV particle


    Target information

    Target IDGM-T25265
    Target NameEZH2
    Gene ID2146,14056,312299,709075,475511,101087309,509106,100051290
    Gene Symbol and SynonymsENX-1,ENX1,Enx1h,EZH2,EZH2b,KMT6,KMT6A,mKIAA4065,WVS,WVS2
    Uniprot AccessionQ15910
    Uniprot Entry NameEZH2_HUMAN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000106462
    Target ClassificationTumor-associated antigen (TAA)

    The target: EZH2, gene name: EZH2, also named as ENX-1, ENX1b, KMT6, KMT6A, WVS, WVS2, EZH2. This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.