Anti-MDR1/ ABCB1/ ABC20 monoclonal antibody

Anti-MDR1/ ABCB1/ ABC20 antibody for FACS & in-vivo assay

Target products collectionGo to ABCB1/ABCB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T25258-Ab-1/ GM-Tg-hg-T25258-Ab-2Anti-Human ABCB1 monoclonal antibodyHuman
GM-Tg-rg-T25258-Ab-1/ GM-Tg-rg-T25258-Ab-2Anti-Rat ABCB1 monoclonal antibodyRat
GM-Tg-mg-T25258-Ab-1/ GM-Tg-mg-T25258-Ab-2Anti-Mouse ABCB1 monoclonal antibodyMouse
GM-Tg-cynog-T25258-Ab-1/ GM-Tg-cynog-T25258-Ab-2Anti-Cynomolgus/ Rhesus macaque ABCB1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T25258-Ab-1/ GM-Tg-felg-T25258-Ab-2Anti-Feline ABCB1 monoclonal antibodyFeline
GM-Tg-cang-T25258-Ab-1/ GM-Tg-cang-T25258-Ab-2Anti-Canine ABCB1 monoclonal antibodyCanine
GM-Tg-bovg-T25258-Ab-1/ GM-Tg-bovg-T25258-Ab-2Anti-Bovine ABCB1 monoclonal antibodyBovine
GM-Tg-equg-T25258-Ab-1/ GM-Tg-equg-T25258-Ab-2Anti-Equine ABCB1 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T25258-Ab-1/ GM-Tg-hg-T25258-Ab-2; GM-Tg-rg-T25258-Ab-1/ GM-Tg-rg-T25258-Ab-2;
GM-Tg-mg-T25258-Ab-1/ GM-Tg-mg-T25258-Ab-2; GM-Tg-cynog-T25258-Ab-1/ GM-Tg-cynog-T25258-Ab-2;
GM-Tg-felg-T25258-Ab-1/ GM-Tg-felg-T25258-Ab-2; GM-Tg-cang-T25258-Ab-1/ GM-Tg-cang-T25258-Ab-2;
GM-Tg-bovg-T25258-Ab-1/ GM-Tg-bovg-T25258-Ab-2; GM-Tg-equg-T25258-Ab-1/ GM-Tg-equg-T25258-Ab-2
Products NameAnti-ABCB1 monoclonal antibody
Formatmab
Target NameABCB1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ABCB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species MDR1/ ABCB1/ ABC20 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLV000440human ABCB1 Lentivirus particle
    ORF Viral VectorpGMLV000440human ABCB1 Lentivirus plasmid


    Target information

    Target IDGM-T25258
    Target NameABCB1
    Gene ID5243,18669,574235,403879,493707,100034074
    Gene Symbol and SynonymsABC20,ABCB1,Abcb1b,CD243,CLCS,GP170,mdr,MDR1,Mdr1b,p-170,P-GP,Pgy-1,PGY1
    Uniprot AccessionP08183
    Uniprot Entry NameMDR1_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000085563
    Target ClassificationTumor-associated antigen (TAA)

    The target: ABCB1, gene name: ABCB1, also named as ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.