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Anti-MDR1/ ABCB1/ ABC20 monoclonal antibody
Anti-MDR1/ ABCB1/ ABC20 antibody for FACS & in-vivo assay
Go to ABCB1/ABCB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T25258-Ab-1/ GM-Tg-hg-T25258-Ab-2 | Anti-Human ABCB1 monoclonal antibody | Human |
| GM-Tg-rg-T25258-Ab-1/ GM-Tg-rg-T25258-Ab-2 | Anti-Rat ABCB1 monoclonal antibody | Rat |
| GM-Tg-mg-T25258-Ab-1/ GM-Tg-mg-T25258-Ab-2 | Anti-Mouse ABCB1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T25258-Ab-1/ GM-Tg-cynog-T25258-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ABCB1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T25258-Ab-1/ GM-Tg-felg-T25258-Ab-2 | Anti-Feline ABCB1 monoclonal antibody | Feline |
| GM-Tg-cang-T25258-Ab-1/ GM-Tg-cang-T25258-Ab-2 | Anti-Canine ABCB1 monoclonal antibody | Canine |
| GM-Tg-bovg-T25258-Ab-1/ GM-Tg-bovg-T25258-Ab-2 | Anti-Bovine ABCB1 monoclonal antibody | Bovine |
| GM-Tg-equg-T25258-Ab-1/ GM-Tg-equg-T25258-Ab-2 | Anti-Equine ABCB1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T25258-Ab-1/ GM-Tg-hg-T25258-Ab-2; GM-Tg-rg-T25258-Ab-1/ GM-Tg-rg-T25258-Ab-2; GM-Tg-mg-T25258-Ab-1/ GM-Tg-mg-T25258-Ab-2; GM-Tg-cynog-T25258-Ab-1/ GM-Tg-cynog-T25258-Ab-2; GM-Tg-felg-T25258-Ab-1/ GM-Tg-felg-T25258-Ab-2; GM-Tg-cang-T25258-Ab-1/ GM-Tg-cang-T25258-Ab-2; GM-Tg-bovg-T25258-Ab-1/ GM-Tg-bovg-T25258-Ab-2; GM-Tg-equg-T25258-Ab-1/ GM-Tg-equg-T25258-Ab-2 |
| Products Name | Anti-ABCB1 monoclonal antibody |
| Format | mab |
| Target Name | ABCB1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ABCB1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MDR1/ ABCB1/ ABC20 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000440 | human ABCB1 Lentivirus particle |
| ORF Viral Vector | pGMLV000440 | human ABCB1 Lentivirus plasmid |
Target information
| Target ID | GM-T25258 |
| Target Name | ABCB1 |
| Gene ID | 5243,18669,574235,403879,493707,100034074 |
| Gene Symbol and Synonyms | ABC20,ABCB1,Abcb1b,CD243,CLCS,GP170,mdr,MDR1,Mdr1b,p-170,P-GP,Pgy-1,PGY1 |
| Uniprot Accession | P08183 |
| Uniprot Entry Name | MDR1_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000085563 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: ABCB1, gene name: ABCB1, also named as ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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