Anti-IL33/ C9orf26/ DVS27 functional antibody

Anti-IL33/ C9orf26/ DVS27 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to IL33/IL33 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T23797-Ab-1/ GM-Tg-hg-T23797-Ab-2Anti-Human IL33 monoclonal antibodyHuman
GM-Tg-rg-T23797-Ab-1/ GM-Tg-rg-T23797-Ab-2Anti-Rat IL33 monoclonal antibodyRat
GM-Tg-mg-T23797-Ab-1/ GM-Tg-mg-T23797-Ab-2Anti-Mouse IL33 monoclonal antibodyMouse
GM-Tg-cynog-T23797-Ab-1/ GM-Tg-cynog-T23797-Ab-2Anti-Cynomolgus/ Rhesus macaque IL33 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T23797-Ab-1/ GM-Tg-felg-T23797-Ab-2Anti-Feline IL33 monoclonal antibodyFeline
GM-Tg-cang-T23797-Ab-1/ GM-Tg-cang-T23797-Ab-2Anti-Canine IL33 monoclonal antibodyCanine
GM-Tg-bovg-T23797-Ab-1/ GM-Tg-bovg-T23797-Ab-2Anti-Bovine IL33 monoclonal antibodyBovine
GM-Tg-equg-T23797-Ab-1/ GM-Tg-equg-T23797-Ab-2Anti-Equine IL33 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T23797-Ab-1/ GM-Tg-hg-T23797-Ab-2; GM-Tg-rg-T23797-Ab-1/ GM-Tg-rg-T23797-Ab-2;
GM-Tg-mg-T23797-Ab-1/ GM-Tg-mg-T23797-Ab-2; GM-Tg-cynog-T23797-Ab-1/ GM-Tg-cynog-T23797-Ab-2;
GM-Tg-felg-T23797-Ab-1/ GM-Tg-felg-T23797-Ab-2; GM-Tg-cang-T23797-Ab-1/ GM-Tg-cang-T23797-Ab-2;
GM-Tg-bovg-T23797-Ab-1/ GM-Tg-bovg-T23797-Ab-2; GM-Tg-equg-T23797-Ab-1/ GM-Tg-equg-T23797-Ab-2
Products NameAnti-IL33 monoclonal antibody
Formatmab
Target NameIL33
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL33 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-591Pre-Made Tozorakimab biosimilar, Whole mAb, Anti-IL33 Antibody: Anti-C9orf26/DVS27/IL1F11/NF-HEV/NFEHEV therapeutic antibody
    BiosimilarGMP-Bios-ab-588Pre-Made Torudokimab biosimilar, Whole mAb, Anti-IL33 Antibody: Anti-C9orf26/DVS27/IL1F11/NF-HEV/NFEHEV therapeutic antibody
    BiosimilarGMP-Bios-ab-283Pre-Made Itepekimab biosimilar, Whole mAb, Anti-IL33 Antibody: Anti-C9orf26/DVS27/IL1F11/NF-HEV/NFEHEV therapeutic antibody
    Target AntigenGM-Tg-g-T23797-Ag-1Recombinant multi-species IL33/ C9orf26/ DVS27 protein
    CytokineGM-Tg-g-T23797-Ag-1Interleukin 33 (IL33) protein
    ORF Viral VectorvGMLV000045human IL33 Lentivirus particle
    ORF Viral VectorpGMLV000045human IL33 Lentivirus plasmid
    ORF Viral VectorpGMAAV000250house mouse Il33 AAV plasmid
    ORF Viral VectorpGMLPm000320mouse Il33 Lentivirus plasmid
    ORF Viral VectorvGMAAV000250house mouse Il33 AAV particle
    ORF Viral VectorvGMLPm000320mouse Il33 Lentivirus particle


    Target information

    Target IDGM-T23797
    Target NameIL33
    Gene ID90865,77125,361749,717301,403810,101093403,507054,100059908
    Gene Symbol and Synonyms9230117N10Rik,C9orf26,DVS27,Il-33,IL1F11,IL33,NF-HEV,NFEHEV,RGD1311155
    Uniprot AccessionO95760,Q66H70,O97863
    Uniprot Entry NameIL33_HUMAN,IL33_RAT,IL33_CANLF
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000137033
    Target ClassificationN/A

    The target: IL33, gene name: IL33, also named as C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV. The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.