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Anti-GELS/ GSN/ ADF monoclonal antibody
Anti-GELS/ GSN/ ADF antibody for FACS & in-vivo assay
Go to GSN/GSN products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23000-Ab-1/ GM-Tg-hg-T23000-Ab-2 | Anti-Human GSN monoclonal antibody | Human |
| GM-Tg-rg-T23000-Ab-1/ GM-Tg-rg-T23000-Ab-2 | Anti-Rat GSN monoclonal antibody | Rat |
| GM-Tg-mg-T23000-Ab-1/ GM-Tg-mg-T23000-Ab-2 | Anti-Mouse GSN monoclonal antibody | Mouse |
| GM-Tg-cynog-T23000-Ab-1/ GM-Tg-cynog-T23000-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GSN monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23000-Ab-1/ GM-Tg-felg-T23000-Ab-2 | Anti-Feline GSN monoclonal antibody | Feline |
| GM-Tg-cang-T23000-Ab-1/ GM-Tg-cang-T23000-Ab-2 | Anti-Canine GSN monoclonal antibody | Canine |
| GM-Tg-bovg-T23000-Ab-1/ GM-Tg-bovg-T23000-Ab-2 | Anti-Bovine GSN monoclonal antibody | Bovine |
| GM-Tg-equg-T23000-Ab-1/ GM-Tg-equg-T23000-Ab-2 | Anti-Equine GSN monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23000-Ab-1/ GM-Tg-hg-T23000-Ab-2; GM-Tg-rg-T23000-Ab-1/ GM-Tg-rg-T23000-Ab-2; GM-Tg-mg-T23000-Ab-1/ GM-Tg-mg-T23000-Ab-2; GM-Tg-cynog-T23000-Ab-1/ GM-Tg-cynog-T23000-Ab-2; GM-Tg-felg-T23000-Ab-1/ GM-Tg-felg-T23000-Ab-2; GM-Tg-cang-T23000-Ab-1/ GM-Tg-cang-T23000-Ab-2; GM-Tg-bovg-T23000-Ab-1/ GM-Tg-bovg-T23000-Ab-2; GM-Tg-equg-T23000-Ab-1/ GM-Tg-equg-T23000-Ab-2 |
| Products Name | Anti-GSN monoclonal antibody |
| Format | mab |
| Target Name | GSN |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GSN benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species GELS/ GSN/ ADF VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001521 | human GSN Lentivirus plasmid |
| ORF Viral Vector | vGMLP001521 | human GSN Lentivirus particle |
| ORF Viral Vector | pGMLPm004448 | mouse Gsn Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004448 | mouse Gsn Lentivirus particle |
Target information
| Target ID | GM-T23000 |
| Target Name | GSN |
| Gene ID | 2934,227753,296654,699705,474819,101088372,535077,100034186 |
| Gene Symbol and Synonyms | ADF,AGEL,GSN |
| Uniprot Accession | P06396,Q68FP1,Q3SX14,Q28372 |
| Uniprot Entry Name | GELS_HUMAN,GELS_RAT,GELS_BOVIN,GELS_HORSE |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000148180 |
| Target Classification | N/A |
The target: GSN, gene name: GSN, also named as ADF, AGEL. The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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