Anti-TGFB3/ ARVD/ ARVD1 monoclonal antibody

Anti-TGFB3/ ARVD/ ARVD1 antibody for FACS & in-vivo assay

Target products collectionGo to TGFB3/TGFB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T22978-Ab-1/ GM-Tg-hg-T22978-Ab-2Anti-Human TGFB3 monoclonal antibodyHuman
GM-Tg-rg-T22978-Ab-1/ GM-Tg-rg-T22978-Ab-2Anti-Rat TGFB3 monoclonal antibodyRat
GM-Tg-mg-T22978-Ab-1/ GM-Tg-mg-T22978-Ab-2Anti-Mouse TGFB3 monoclonal antibodyMouse
GM-Tg-cynog-T22978-Ab-1/ GM-Tg-cynog-T22978-Ab-2Anti-Cynomolgus/ Rhesus macaque TGFB3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T22978-Ab-1/ GM-Tg-felg-T22978-Ab-2Anti-Feline TGFB3 monoclonal antibodyFeline
GM-Tg-cang-T22978-Ab-1/ GM-Tg-cang-T22978-Ab-2Anti-Canine TGFB3 monoclonal antibodyCanine
GM-Tg-bovg-T22978-Ab-1/ GM-Tg-bovg-T22978-Ab-2Anti-Bovine TGFB3 monoclonal antibodyBovine
GM-Tg-equg-T22978-Ab-1/ GM-Tg-equg-T22978-Ab-2Anti-Equine TGFB3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T22978-Ab-1/ GM-Tg-hg-T22978-Ab-2; GM-Tg-rg-T22978-Ab-1/ GM-Tg-rg-T22978-Ab-2;
GM-Tg-mg-T22978-Ab-1/ GM-Tg-mg-T22978-Ab-2; GM-Tg-cynog-T22978-Ab-1/ GM-Tg-cynog-T22978-Ab-2;
GM-Tg-felg-T22978-Ab-1/ GM-Tg-felg-T22978-Ab-2; GM-Tg-cang-T22978-Ab-1/ GM-Tg-cang-T22978-Ab-2;
GM-Tg-bovg-T22978-Ab-1/ GM-Tg-bovg-T22978-Ab-2; GM-Tg-equg-T22978-Ab-1/ GM-Tg-equg-T22978-Ab-2
Products NameAnti-TGFB3 monoclonal antibody
Formatmab
Target NameTGFB3
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-TGFB3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species TGFB3/ ARVD/ ARVD1 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T22978-Ag-1transforming growth factor, beta 3 (TGFB3) protein
    ORF Viral VectorvGMLP003661human TGFB3 Lentivirus particle
    ORF Viral VectorpGMLP003661human TGFB3 Lentivirus plasmid


    Target information

    Target IDGM-T22978
    Target NameTGFB3
    Gene ID7043,21809,25717,703239,490796,101098469,538957,100051765
    Gene Symbol and SynonymsARVD,ARVD1,LDS5,RNHF,TGF-B3,TGF-beta-3,TGF-beta3,Tgfb-3,TGFB3,TGFbeta3
    Uniprot AccessionP10600,Q07258
    Uniprot Entry NameTGFB3_HUMAN,TGFB3_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseBreast Cancer
    Gene EnsemblENSG00000119699
    Target ClassificationCheckpoint-Immuno Oncology

    The target: TGFB3, gene name: TGFB3, also named as ARVD, ARVD1, LDS5, RNHF, TGF-beta3. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.