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Anti-TGFB3/ ARVD/ ARVD1 monoclonal antibody
Anti-TGFB3/ ARVD/ ARVD1 antibody for FACS & in-vivo assay
Go to TGFB3/TGFB3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T22978-Ab-1/ GM-Tg-hg-T22978-Ab-2 | Anti-Human TGFB3 monoclonal antibody | Human |
| GM-Tg-rg-T22978-Ab-1/ GM-Tg-rg-T22978-Ab-2 | Anti-Rat TGFB3 monoclonal antibody | Rat |
| GM-Tg-mg-T22978-Ab-1/ GM-Tg-mg-T22978-Ab-2 | Anti-Mouse TGFB3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T22978-Ab-1/ GM-Tg-cynog-T22978-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TGFB3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T22978-Ab-1/ GM-Tg-felg-T22978-Ab-2 | Anti-Feline TGFB3 monoclonal antibody | Feline |
| GM-Tg-cang-T22978-Ab-1/ GM-Tg-cang-T22978-Ab-2 | Anti-Canine TGFB3 monoclonal antibody | Canine |
| GM-Tg-bovg-T22978-Ab-1/ GM-Tg-bovg-T22978-Ab-2 | Anti-Bovine TGFB3 monoclonal antibody | Bovine |
| GM-Tg-equg-T22978-Ab-1/ GM-Tg-equg-T22978-Ab-2 | Anti-Equine TGFB3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T22978-Ab-1/ GM-Tg-hg-T22978-Ab-2; GM-Tg-rg-T22978-Ab-1/ GM-Tg-rg-T22978-Ab-2; GM-Tg-mg-T22978-Ab-1/ GM-Tg-mg-T22978-Ab-2; GM-Tg-cynog-T22978-Ab-1/ GM-Tg-cynog-T22978-Ab-2; GM-Tg-felg-T22978-Ab-1/ GM-Tg-felg-T22978-Ab-2; GM-Tg-cang-T22978-Ab-1/ GM-Tg-cang-T22978-Ab-2; GM-Tg-bovg-T22978-Ab-1/ GM-Tg-bovg-T22978-Ab-2; GM-Tg-equg-T22978-Ab-1/ GM-Tg-equg-T22978-Ab-2 |
| Products Name | Anti-TGFB3 monoclonal antibody |
| Format | mab |
| Target Name | TGFB3 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TGFB3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TGFB3/ ARVD/ ARVD1 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T22978-Ag-1 | transforming growth factor, beta 3 (TGFB3) protein |
| ORF Viral Vector | vGMLP003661 | human TGFB3 Lentivirus particle |
| ORF Viral Vector | pGMLP003661 | human TGFB3 Lentivirus plasmid |
Target information
| Target ID | GM-T22978 |
| Target Name | TGFB3 |
| Gene ID | 7043,21809,25717,703239,490796,101098469,538957,100051765 |
| Gene Symbol and Synonyms | ARVD,ARVD1,LDS5,RNHF,TGF-B3,TGF-beta-3,TGF-beta3,Tgfb-3,TGFB3,TGFbeta3 |
| Uniprot Accession | P10600,Q07258 |
| Uniprot Entry Name | TGFB3_HUMAN,TGFB3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Breast Cancer |
| Gene Ensembl | ENSG00000119699 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TGFB3, gene name: TGFB3, also named as ARVD, ARVD1, LDS5, RNHF, TGF-beta3. This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This protein is involved in embryogenesis and cell differentiation, and may play a role in wound healing. Mutations in this gene are a cause of aortic aneurysms and dissections, as well as familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Aug 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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