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Anti-GAD2 monoclonal antibody
Pre-made anti-GAD2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to GAD2/GAD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T22128-Ab-1/ GM-Tg-hg-T22128-Ab-2 | Anti-Human GAD2 monoclonal antibody | Human |
| GM-Tg-rg-T22128-Ab-1/ GM-Tg-rg-T22128-Ab-2 | Anti-Rat GAD2 monoclonal antibody | Rat |
| GM-Tg-mg-T22128-Ab-1/ GM-Tg-mg-T22128-Ab-2 | Anti-Mouse GAD2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T22128-Ab-1/ GM-Tg-cynog-T22128-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GAD2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T22128-Ab-1/ GM-Tg-felg-T22128-Ab-2 | Anti-Feline GAD2 monoclonal antibody | Feline |
| GM-Tg-cang-T22128-Ab-1/ GM-Tg-cang-T22128-Ab-2 | Anti-Canine GAD2 monoclonal antibody | Canine |
| GM-Tg-bovg-T22128-Ab-1/ GM-Tg-bovg-T22128-Ab-2 | Anti-Bovine GAD2 monoclonal antibody | Bovine |
| GM-Tg-equg-T22128-Ab-1/ GM-Tg-equg-T22128-Ab-2 | Anti-Equine GAD2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T22128-Ab-1/ GM-Tg-hg-T22128-Ab-2; GM-Tg-rg-T22128-Ab-1/ GM-Tg-rg-T22128-Ab-2; GM-Tg-mg-T22128-Ab-1/ GM-Tg-mg-T22128-Ab-2; GM-Tg-cynog-T22128-Ab-1/ GM-Tg-cynog-T22128-Ab-2; GM-Tg-felg-T22128-Ab-1/ GM-Tg-felg-T22128-Ab-2; GM-Tg-cang-T22128-Ab-1/ GM-Tg-cang-T22128-Ab-2; GM-Tg-bovg-T22128-Ab-1/ GM-Tg-bovg-T22128-Ab-2; GM-Tg-equg-T22128-Ab-1/ GM-Tg-equg-T22128-Ab-2 |
| Products Name | Anti-GAD2 monoclonal antibody |
| Format | mab |
| Target Name | GAD2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-GAD2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T22128-Ag-1 | Recombinant multi-species DCE2/ GAD2/ GAD65 protein |
| ORF Viral Vector | pGMLP003929 | human GAD2 Lentivirus plasmid |
| ORF Viral Vector | vGMLP003929 | human GAD2 Lentivirus particle |
| ORF Viral Vector | pGMLPm004442 | mouse Gad2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004442 | mouse Gad2 Lentivirus particle |
Target information
| Target ID | GM-T22128 |
| Target Name | GAD2 |
| Gene ID | 2572,14417,24380,613029,487107,101082244,512459,100055419 |
| Gene Symbol and Synonyms | 6330404F12Rik,GAD(65),Gad-2,GAD2,GAD65 |
| Uniprot Accession | Q05329,Q05683,Q4PRC2 |
| Uniprot Entry Name | DCE2_HUMAN,DCE2_RAT,DCE2_CANLF |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000136750 |
| Target Classification | N/A |
The target: GAD2, gene name: GAD2, also named as GAD65. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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