Anti-ATG7/ APG7-LIKE/ APG7L functional antibody

Anti-ATG7/ APG7-LIKE/ APG7L functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to ATG7/ATG7 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T20302-Ab-1/ GM-Tg-hg-T20302-Ab-2Anti-Human ATG7 monoclonal antibodyHuman
GM-Tg-rg-T20302-Ab-1/ GM-Tg-rg-T20302-Ab-2Anti-Rat ATG7 monoclonal antibodyRat
GM-Tg-mg-T20302-Ab-1/ GM-Tg-mg-T20302-Ab-2Anti-Mouse ATG7 monoclonal antibodyMouse
GM-Tg-cynog-T20302-Ab-1/ GM-Tg-cynog-T20302-Ab-2Anti-Cynomolgus/ Rhesus macaque ATG7 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T20302-Ab-1/ GM-Tg-felg-T20302-Ab-2Anti-Feline ATG7 monoclonal antibodyFeline
GM-Tg-cang-T20302-Ab-1/ GM-Tg-cang-T20302-Ab-2Anti-Canine ATG7 monoclonal antibodyCanine
GM-Tg-bovg-T20302-Ab-1/ GM-Tg-bovg-T20302-Ab-2Anti-Bovine ATG7 monoclonal antibodyBovine
GM-Tg-equg-T20302-Ab-1/ GM-Tg-equg-T20302-Ab-2Anti-Equine ATG7 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T20302-Ab-1/ GM-Tg-hg-T20302-Ab-2; GM-Tg-rg-T20302-Ab-1/ GM-Tg-rg-T20302-Ab-2;
GM-Tg-mg-T20302-Ab-1/ GM-Tg-mg-T20302-Ab-2; GM-Tg-cynog-T20302-Ab-1/ GM-Tg-cynog-T20302-Ab-2;
GM-Tg-felg-T20302-Ab-1/ GM-Tg-felg-T20302-Ab-2; GM-Tg-cang-T20302-Ab-1/ GM-Tg-cang-T20302-Ab-2;
GM-Tg-bovg-T20302-Ab-1/ GM-Tg-bovg-T20302-Ab-2; GM-Tg-equg-T20302-Ab-1/ GM-Tg-equg-T20302-Ab-2
Products NameAnti-ATG7 monoclonal antibody
Formatmab
Target NameATG7
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ATG7 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T20302-Ag-1Recombinant multi-species ATG7/ APG7-LIKE/ APG7L protein
    ORF Viral VectorpGMAD000194human ATG7 Adenovirus plasmid
    ORF Viral VectorvGMLV000516human ATG7 Lentivirus particle
    ORF Viral VectorpGMLV000190human ATG7 Lentivirus plasmid
    ORF Viral VectorpGMLV000516human ATG7 Lentivirus plasmid
    ORF Viral VectorvGMLV000190human ATG7 Lentivirus particle
    ORF Viral VectorvGMAD000194human ATG7 Adenovirus particle
    ORF Viral VectorpGMAD000030rat Atg7 Adenovirus plasmid
    ORF Viral VectorpGMAD000420Norway rat Atg7 Adenovirus plasmid
    ORF Viral VectorpGMAAV000084mouse Atg7 AAV plasmid
    ORF Viral VectorvGMAD000030rat Atg7 Adenovirus particle
    ORF Viral VectorvGMAD000420Norway rat Atg7 Adenovirus particle
    ORF Viral VectorvGMAAV000084mouse Atg7 AAV particle


    Target information

    Target IDGM-T20302
    Target NameATG7
    Gene ID10533,74244,312647,696238,476533,101093088,787967,100051544
    Gene Symbol and Synonyms1810013K23Rik,Agp7,APG7-LIKE,APG7L,ATG7,Atg7l,Gm21553,GSA7,SCAR31
    Uniprot AccessionO95352,Q641Y5
    Uniprot Entry NameATG7_HUMAN,ATG7_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000197548
    Target ClassificationTumor-associated antigen (TAA)

    The target: ATG7, gene name: ATG7, also named as APG7-LIKE, APG7L, GSA7. This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.