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Anti-TNFC/ LTB/ TNFSF3 monoclonal antibody
Anti-TNFC/ LTB/ TNFSF3 antibody for FACS & in-vivo assay
Go to LTB/LTB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T20221-Ab-1/ GM-Tg-hg-T20221-Ab-2 | Anti-Human LTB monoclonal antibody | Human |
| GM-Tg-rg-T20221-Ab-1/ GM-Tg-rg-T20221-Ab-2 | Anti-Rat LTB monoclonal antibody | Rat |
| GM-Tg-mg-T20221-Ab-1/ GM-Tg-mg-T20221-Ab-2 | Anti-Mouse LTB monoclonal antibody | Mouse |
| GM-Tg-cynog-T20221-Ab-1/ GM-Tg-cynog-T20221-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LTB monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T20221-Ab-1/ GM-Tg-felg-T20221-Ab-2 | Anti-Feline LTB monoclonal antibody | Feline |
| GM-Tg-cang-T20221-Ab-1/ GM-Tg-cang-T20221-Ab-2 | Anti-Canine LTB monoclonal antibody | Canine |
| GM-Tg-bovg-T20221-Ab-1/ GM-Tg-bovg-T20221-Ab-2 | Anti-Bovine LTB monoclonal antibody | Bovine |
| GM-Tg-equg-T20221-Ab-1/ GM-Tg-equg-T20221-Ab-2 | Anti-Equine LTB monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T20221-Ab-1/ GM-Tg-hg-T20221-Ab-2; GM-Tg-rg-T20221-Ab-1/ GM-Tg-rg-T20221-Ab-2; GM-Tg-mg-T20221-Ab-1/ GM-Tg-mg-T20221-Ab-2; GM-Tg-cynog-T20221-Ab-1/ GM-Tg-cynog-T20221-Ab-2; GM-Tg-felg-T20221-Ab-1/ GM-Tg-felg-T20221-Ab-2; GM-Tg-cang-T20221-Ab-1/ GM-Tg-cang-T20221-Ab-2; GM-Tg-bovg-T20221-Ab-1/ GM-Tg-bovg-T20221-Ab-2; GM-Tg-equg-T20221-Ab-1/ GM-Tg-equg-T20221-Ab-2 |
| Products Name | Anti-LTB monoclonal antibody |
| Format | mab |
| Target Name | LTB |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LTB benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TNFC/ LTB/ TNFSF3 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T20221-Ag-1 | lymphotoxin beta (TNF superfamily, member 3) (LTB) protein |
| ORF Viral Vector | pGMLP004791 | human Ltb Lentivirus plasmid |
| ORF Viral Vector | vGMLP004791 | human Ltb Lentivirus particle |
| ORF Viral Vector | pGMLPm003675 | mouse Ltb Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003675 | mouse Ltb Lentivirus particle |
Target information
| Target ID | GM-T20221 |
| Target Name | LTB |
| Gene ID | 4050,16994,361795,715518,481712,101085208,529757,100058364 |
| Gene Symbol and Synonyms | LTB,LTbeta,p33,TNFC,TNFSF3,TNLG1C |
| Uniprot Accession | Q06643,Q5™22 |
| Uniprot Entry Name | TNFC_HUMAN,TNFC_MACMU |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000227507 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LTB, gene name: LTB, also named as TNFC, TNFSF3, TNLG1C, p33. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. The predominant form on the lymphocyte surface is the lymphotoxin-alpha 1/beta 2 complex (e.g. 1 molecule alpha/2 molecules beta) and this complex is the primary ligand for the lymphotoxin-beta receptor. The minor complex is lymphotoxin-alpha 2/beta 1. LTB is an inducer of the inflammatory response system and involved in normal development of lymphoid tissue. Lymphotoxin-beta isoform b is unable to complex with lymphotoxin-alpha suggesting a function for lymphotoxin-beta which is independent of lympyhotoxin-alpha. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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