Anti-TNNI3 monoclonal antibody

Pre-made anti-TNNI3 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to TNNI3/TNNI3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T20186-Ab-1/ GM-Tg-hg-T20186-Ab-2Anti-Human TNNI3 monoclonal antibodyHuman
GM-Tg-rg-T20186-Ab-1/ GM-Tg-rg-T20186-Ab-2Anti-Rat TNNI3 monoclonal antibodyRat
GM-Tg-mg-T20186-Ab-1/ GM-Tg-mg-T20186-Ab-2Anti-Mouse TNNI3 monoclonal antibodyMouse
GM-Tg-cynog-T20186-Ab-1/ GM-Tg-cynog-T20186-Ab-2Anti-Cynomolgus/ Rhesus macaque TNNI3 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T20186-Ab-1/ GM-Tg-felg-T20186-Ab-2Anti-Feline TNNI3 monoclonal antibodyFeline
GM-Tg-cang-T20186-Ab-1/ GM-Tg-cang-T20186-Ab-2Anti-Canine TNNI3 monoclonal antibodyCanine
GM-Tg-bovg-T20186-Ab-1/ GM-Tg-bovg-T20186-Ab-2Anti-Bovine TNNI3 monoclonal antibodyBovine
GM-Tg-equg-T20186-Ab-1/ GM-Tg-equg-T20186-Ab-2Anti-Equine TNNI3 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T20186-Ab-1/ GM-Tg-hg-T20186-Ab-2; GM-Tg-rg-T20186-Ab-1/ GM-Tg-rg-T20186-Ab-2;
GM-Tg-mg-T20186-Ab-1/ GM-Tg-mg-T20186-Ab-2; GM-Tg-cynog-T20186-Ab-1/ GM-Tg-cynog-T20186-Ab-2;
GM-Tg-felg-T20186-Ab-1/ GM-Tg-felg-T20186-Ab-2; GM-Tg-cang-T20186-Ab-1/ GM-Tg-cang-T20186-Ab-2;
GM-Tg-bovg-T20186-Ab-1/ GM-Tg-bovg-T20186-Ab-2; GM-Tg-equg-T20186-Ab-1/ GM-Tg-equg-T20186-Ab-2
Products NameAnti-TNNI3 monoclonal antibody
Formatmab
Target NameTNNI3
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody, Diagnostic target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-TNNI3 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T20186-Ag-1Recombinant multi-species TNNI3/ CMD1FF/ CMD2A protein
    ORF Viral VectorpGMLP002894human TNNI3 Lentivirus plasmid
    ORF Viral VectorvGMLP002894human TNNI3 Lentivirus particle
    ORF Viral VectorpGMLPm001568mouse Tnni3 Lentivirus plasmid
    ORF Viral VectorvGMLPm001568mouse Tnni3 Lentivirus particle


    Target information

    Target IDGM-T20186
    Target NameTNNI3
    Gene ID7137,21954,29248,698470,403566,493744,511094,100034065
    Gene Symbol and SynonymsCMD1FF,CMD2A,CMH7,cTnI,RCM1,Tn1,TnI,TNNC1,TNNI3
    Uniprot AccessionP19429,P23693,Q8MKD5,Q863B6,P08057,Q5PYI0
    Uniprot Entry NameTNNI3_HUMAN,TNNI3_RAT,TNNI3_FELCA,TNNI3_CANLF,TNNI3_BOVIN,TNNI3_HORSE
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target, Diagnostics Biomarker
    DiseaseN/A
    Gene EnsemblENSG00000129991
    Target ClassificationN/A

    The target: TNNI3, gene name: TNNI3, also named as CMD1FF, CMD2A, CMH7, RCM1, TNNC1, cTnI. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.