Anti-ONCM/ OSM functional antibody

Anti-ONCM/ OSM functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to OSM/OSM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T19556-Ab-1/ GM-Tg-hg-T19556-Ab-2Anti-Human OSM monoclonal antibodyHuman
GM-Tg-rg-T19556-Ab-1/ GM-Tg-rg-T19556-Ab-2Anti-Rat OSM monoclonal antibodyRat
GM-Tg-mg-T19556-Ab-1/ GM-Tg-mg-T19556-Ab-2Anti-Mouse OSM monoclonal antibodyMouse
GM-Tg-cynog-T19556-Ab-1/ GM-Tg-cynog-T19556-Ab-2Anti-Cynomolgus/ Rhesus macaque OSM monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T19556-Ab-1/ GM-Tg-felg-T19556-Ab-2Anti-Feline OSM monoclonal antibodyFeline
GM-Tg-cang-T19556-Ab-1/ GM-Tg-cang-T19556-Ab-2Anti-Canine OSM monoclonal antibodyCanine
GM-Tg-bovg-T19556-Ab-1/ GM-Tg-bovg-T19556-Ab-2Anti-Bovine OSM monoclonal antibodyBovine
GM-Tg-equg-T19556-Ab-1/ GM-Tg-equg-T19556-Ab-2Anti-Equine OSM monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T19556-Ab-1/ GM-Tg-hg-T19556-Ab-2; GM-Tg-rg-T19556-Ab-1/ GM-Tg-rg-T19556-Ab-2;
GM-Tg-mg-T19556-Ab-1/ GM-Tg-mg-T19556-Ab-2; GM-Tg-cynog-T19556-Ab-1/ GM-Tg-cynog-T19556-Ab-2;
GM-Tg-felg-T19556-Ab-1/ GM-Tg-felg-T19556-Ab-2; GM-Tg-cang-T19556-Ab-1/ GM-Tg-cang-T19556-Ab-2;
GM-Tg-bovg-T19556-Ab-1/ GM-Tg-bovg-T19556-Ab-2; GM-Tg-equg-T19556-Ab-1/ GM-Tg-equg-T19556-Ab-2
Products NameAnti-OSM monoclonal antibody
Formatmab
Target NameOSM
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-OSM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T19556-Ag-1Recombinant multi-species ONCM/ OSM protein
    CytokineGM-Tg-g-T19556-Ag-1oncostatin M (OSM) protein
    ORF Viral VectorvGMAP000088Human OSM Adenovirus particle
    ORF Viral VectorvGMLP000497human OSM Lentivirus particle
    ORF Viral VectorpGMLP000497human OSM Lentivirus plasmid
    ORF Viral VectorpGMAP000088Human OSM Adenovirus plasmid
    ORF Viral VectorpGMLV000636house mouse osm Lentivirus plasmid
    ORF Viral VectorpGMLPm001269mouse Osm Lentivirus plasmid
    ORF Viral VectorvGMLV000636house mouse osm Lentivirus particle
    ORF Viral VectorvGMLPm001269mouse Osm Lentivirus particle


    Target information

    Target IDGM-T19556
    Target NameOSM
    Gene ID5008,18413,289747,717994,611921,101094379,319086,100064031
    Gene Symbol and SynonymsOncoM,OSM
    Uniprot AccessionP13725,Q65Z15,P53346
    Uniprot Entry NameONCM_HUMAN,ONCM_RAT,ONCM_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000099985
    Target ClassificationN/A

    The target: OSM, gene name: OSM, also named as . This gene encodes a member of the leukemia inhibitory factor/oncostatin-M (LIF/OSM) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein is a secreted cytokine and growth regulator that inhibits the proliferation of a number of tumor cell lines. This protein also regulates the production of other cytokines, including interleukin 6, granulocyte-colony stimulating factor and granulocyte-macrophage colony stimulating factor in endothelial cells. This gene and the related gene, leukemia inhibitory factor, also present on chromosome 22, may have resulted from the duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.